武当中药夏枯草治疗桥本甲状腺炎作用机制的网络药理学研究  

A Network Pharmacological Study on the Mechanism of Wudang Chinese Medicine Prunella Vulgaris in the Treat⁃ment of Hashimoto′s Thyroiditis

作　　者：李志 黑丽 庞江鑫 李雪锋[3] 王艳 周欢欢 李雯娟 顾新生 LI Zhi;HEI Li;PANG Jiang-xin;LI Xue-feng;WANG Yan;ZHOU Huan-huan;LI Wen-juan;GU Xin-sheng(Department of Pharmacology,School of Basic Medical Sciences,Shiyan,Hubei 442000,China;First Clinical College,Shiyan,Hubei 442000,China;Department of Endocrinology,Taihe Hospital,Shiyan,Hubei 442000,China;Department of Laboratory,Dongfeng Hospial,Shiyan,Hubei 442000,China;Department of Pathology,Dongfeng Hospital,Hubei Uniersity of Medicine,Shiyan,Hubei 442000,China)

机构地区：[1]湖北医药学院基础医学院药理学教研室,湖北十堰442000 [2]湖北医药学院第一临床学院,湖北十堰442000 [3]湖北医药学院附属太和医院内分泌科,湖北十堰442000 [4]湖北医药学院附属东风医院检验科,湖北十堰442000 [5]湖北医药学院附属东风医院病理科,湖北十堰442000

出　　处：《湖北医药学院学报》2020年第4期327-333,F0003,共8页Journal of Hubei University of Medicine

基　　金：湖北省省级大学生创新创业训练计划项目(S201910929047);十堰市科技局引导性项目(18Y95);湖北医药学院人才启动金项目资助(2019QDJZR07);湖北医药学院学生科研基金。

摘　　要：目的:探讨夏枯草治疗桥本甲状腺炎的网络药理学机制。方法:使用TCMSP、GeneCards与OMIM等数据库查询并分析夏枯草生物利用度和类药性较高的活性成分及其对桥本甲状腺炎作用的靶点,分析靶点的GO(gene ontology)生物学过程及KEGG通路。结果:筛得化学成分11个,靶向夏枯草治疗桥本甲状腺炎的53个靶标。显著富集GO生物学过程条目1600多个,包括对脂多糖、有毒物质、细菌来源分子的反应和生殖结构、生殖系统发育等。显著富集KEGG信号通路44条,包括EGFR酪氨酸激酶抑制剂抵抗、IL-17信号通路等。结论:本研究揭示了参与夏枯草治疗桥本甲状腺炎的多活性成分、多靶点、多个生物学过程及信号通路,将为进一步全面研究和验证夏枯草治疗桥本甲状腺炎疗效的潜在分子机制提供线索。Objective To investigate the network pharmacological mechanism of Prunella vulgaris in the treatment of Hashi⁃moto′s thyroiditis.Methods TCMSP(Traditional Chinese Medicine Systems Pharmacology),GeneCards and OMIM data⁃bases were used to query and analyze the active components of Prunella vulgaris with high bioavailability and drug-like properties of Prunella vulgaris and their targets for Hashimoto′s thyroiditis,and analyze the GO(gene ontology)biological processes of the targets and KEGG pathway.Results A total of 11 chemical components were obtained from screening and 53 targets of Prunella vulgaris were identified for the treatment of Hashimoto′s thyroiditis.More than 1600 gene ontology bi⁃ological process items were significantly enriched,including the responses to lipopolysaccharide,toxic substances,bacterial-derived molecules,reproductive structure and reproductive system development,etc.44 KEGG(Kyoto Encyclopedia of Genes and Genomes)signaling pathways were significantly enriched,including EGFR tyrosine kinase inhibitor resistance and IL-17 signaling pathway.Conclusion This study revealed multiple active components,multiple targets,multiple bio⁃logical processes and signaling pathways involved in the treatment of Hashimoto′s thyroiditis by Prunella vulgaris,which will provide clues for further comprehensive study and verification of the potential molecular mechanism of Prunella vulgaris in the treatment of Hashimoto′s thyroiditis.

关 键 词：夏枯草 桥本甲状腺炎 药理学机制 

分 类 号：R285[医药卫生—中药学]