钯催化咔唑的乙酰氧化合成新方法  

A New Method for the Synthesis of Acetoxylation of Carbazole Catalyzed by Palladium

作　　者：高文梅 李彬 张武霞 郭冬冬 GAO Wen-mei;LI Bin;ZHANG Wu-xia;GUO Dong-dong(College of Arts and Sciences,Shanxi Agricultural University,Jinzhong 030801,China)

机构地区：[1]山西农业大学文理学院,山西晋中030801

出　　处：《合成化学》2020年第7期594-599,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金青年基金资助项目(31800678);山西省优秀博士来晋工作奖励(SXYBKY201737,SXYBKY201706);山西省青年基金资助项目(201801D221062);山西农业大学科技创新项目(2017YJ38,2017YJ41);山西省高等学校科技创新项目(2019L0374)。

摘　　要：报道了以钯(Ⅱ)为催化剂的咔唑分子间直接乙酰氧基化反应的通用高效方法。以醋酸钯为催化剂,过硫酸钾为氧化剂,2-吡啶磺酰基作为导向基团,以85%和83%的收率合成单乙酰氧基化和双乙酰氧基化产物。结构经1 H NMR,13 C NMR,IR和HR-MS(ESI)表征。A general and efficient method for direct acetylation of carbazole with palladium(Ⅱ)as catalyst is reported.In this reaction,palladium acetate was used as catalyst,potassium persulfate as oxidant,2-pyridylsulfonyl as guiding group,and the products of monoacetoxylation and diacetoxylation were synthesized in yield of 85%and 83%.The structure was characterized by 1 H NMR,13 C NMR,IR and HR-MS(ESI).

关 键 词：咔唑 乙酰氧化 醋酸钯 过硫酸钾 2-吡啶磺酰基 导向基团 合成 

分 类 号：O621.3[理学—有机化学] O626[理学—化学]