钽与钛(合金)骨科材料的差异比较:理化指标及抗菌和成骨能力  

Comparison of tantalum and titanium(alloy)as orthopedic materials:physical and chemical indexes,antibacterial and osteogenic ability

作　　者：石晓岫 毛世龙 刘洋[1] 马幸双 罗彦凤[1] Shi Xiaoxiu;Mao Shilong;Liu Yang;Ma Xingshuang;Luo Yanfeng(Key Laboratory of Biorheological Science and Technology of Ministry of Education,College of Bioengineering,Chongqing University,Chongqing 400044,China)

机构地区：[1]重庆大学生物工程学院,生物流变科学与技术教育部重点实验室,重庆市400044

出　　处：《中国组织工程研究》2021年第4期593-599,共7页Chinese Journal of Tissue Engineering Research

基　　金：“十三五”国家重点研发计划课题(2016YFB1101401),项目负责人:罗彦凤。

摘　　要：背景:钽和钛(合金)是目前临床应用最广泛的骨科生物材料,尤其是钽基生物材料,以其优异的耐腐蚀性和骨整合性而被临床医生所青睐。但有关钽基生物材料在骨科应用中是否优于钛(合金),现有研究并无定论。目的:综述比较性研究钽与钛(合金)生物学性能的文献,分析造成钽和钛(合金)材料体内外生物相容性异同的可能原因。方法:应用计算机在中国知网、万方、PubMed数据库检索涉及比较性研究钽和钛(合金)的体内外生物学性能的相关文献,检索题目中含有"钽(tantalum)"且题目或摘要中含有"钛(titanium)",即(tantalum[Title])AND(titanium[Title/Abstract])的文献,检索截止时间为2020年1月。结果与结论:在关于比较性研究钽和钛(合金)生物学性能的文献中,临床观察、动物实验、细胞实验结果的结论主要分为2类,一类是认为钽的促成骨能力和抗菌活性优于钛(合金),另一类认为钽与钛(合金)具有相似的促成骨能力和抗菌活性。造成这两种差异性结果的原因主要是钽和钛(合金)的加工方法和表面化学组成、拓扑结构或孔结构等理化性能指标存在差异。BACKGROUND:Tantalum and titanium(alloy)are the most widely employed metallic biomaterials in orthopedics.Tantalum is especially focused because of its excellent corrosion resistance and osteointegration.However,whether tantalum is better than titanium(alloy)as orthopedic materials is still in dispute.OBJECTIVE:To review the comparative studies on the biological performances of tantalum and titanium(alloy)and analyze the possible causes of the similarities and differences of biocompatibility of tantalum and titanium(alloy)materials in vivo and in vitro.METHODS:A computer-based search of CNKI,Wanfang and PubMed database was performed for articles relating to the comparative studies on the biological performances of tantalum and titanium(alloy)published until January 2020.The search words were“tantalum”in title and“titanium”in title or abstract,i.e.,(tantalum[Title])AND(titanium[Title/Abstract]).RESULTS AND CONCLUSION:Among the comparative studies on the biological performances of tantalum and titanium(alloy),two viewpoints were primarily involved according to the results from clinical follow-up,animal tests,and cellular experiments.One is that tantalum is superior to titanium(alloy)with better osteogenesis and bone formation and stronger antibacterial activity,while the other one is that tantalum has similar osteogenesis and bone formation and antibacterial activity to titanium(alloy).The primary reason responsible for this divergence is that the fabrication method and the surface chemistries,topographical structures or pore structures are different between the employed tantalum and titanium(alloy).

关 键 词：骨 材料 钛 钛合金 钽 钽涂层 骨科 成骨性 骨整合性 抗菌性 

分 类 号：R459.9[医药卫生—治疗学] R-1[医药卫生—临床医学]