海藻酸盐基水凝胶/敷料在创面愈合中的应用:持续、动态与顺序释放  

Application of alginate based hydrogels/dressings in wound healing:sustained,dynamic and sequential release

作　　者：张振坤 李喆 李亚 王莹莹 王亚苹 周馨魁 马珊珊 关方霞 Zhang Zhenkun;Li Zhe;Li Ya;Wang Yingying;Wang Yaping;Zhou Xinkui;Ma Shanshan;Guan Fangxia(School of Life Sciences,Zhengzhou University,Zhengzhou 450001,Henan Province,China)

机构地区：[1]郑州大学生命科学学院,河南省郑州市450001

出　　处：《中国组织工程研究》2021年第4期638-643,共6页Chinese Journal of Tissue Engineering Research

基　　金：河南省重点研发与推广专项科技攻关(202102310211),项目负责人:马珊珊;河南省中原千人-科技创新领军人才支持项目(204200510013),项目负责人:关方霞。

摘　　要：背景:海藻酸盐可以改善创面敷料的亲水性质、创造湿润的创面微环境、清除创面渗出物。目前,海藻酸盐生物高分子材料已被应用于多种创面敷料的设计和开发,以提高创面愈合的效率。目的:总结海藻酸盐基水凝胶/敷料在皮肤创面愈合中的研究及进展。方法:应用计算机检索2000至2020年PubMed、Science Direct和CNKI等数据库中的相关文章,英文检索词为“Alginate hydrogel,Wound healing,Wound dressing,Mesenchymal stem cell,Growth factor,Nanoparticles,Diabetic wound,Antibiotics,Bioactive peptide,threedimensional printing”,中文检索词为“海藻酸盐、创面修复”。根据纳入与排除标准最终保留60篇文献进行综述。结果与结论:①海藻酸盐与其他有机或无机材料发生交联可提高复合材料的机械性能和生物降解性,创造湿润温和的创面微环境;②海藻酸盐基水凝胶/敷料可以作为传递平台负载种子细胞、生长因子或其他生物活性物质,加快创面愈合的速度;③如何使海藻酸盐材料具有较多的细胞识别位点,如何改善复合支架材料的力学性能,如何控制海藻酸盐生物材料的微观结构及如何控制药物或细胞的动态释放、持续释放和顺序释放等问题,仍需研究者们进一步探索。BACKGROUND:Alginate can improve the hydrophilic quality of wound dressing,create moist wound microenvironment,and remove wound exudate.Currently,alginate bimolecular materials have been used in the design and development of various wound dressings to improve the efficiency of wound healing.OBJECTIVE:To summarize the research and progress of alginate based hydrogels/dressings in skin wound healing.METHODS:We searched PubMed,Science Direct and CNKI databases from 2000 to 2020 with the English terms of“alginate hydrogel,wound healing,wound dressing,mesenchymal stem cell,growth factor,nanoparticles,diabetic wound,antibiotics,bioactive peptide,three-dimensional printing”and the Chinese terms of“alginate,wound healing”.Based on the inclusion and exclusion criteria,60 articles were finally reserved for review.RESULTS AND CONCLUSION:(1)The cross-linking of alginate with other organic or inorganic materials can improve the mechanical properties and biodegradability of composite materials,and create a moist and mild wound microenvironment.(2)Alginate based hydrogel/dressing can be used as a delivery platform to load seed cells,growth factors or other bioactive substances to speed up wound healing.(3)It still need to be further explored by researchers to make alginate materials have better cell recognition sites,improve the mechanical properties of composite scaffold materials,control the microstructure of alginate biomaterials and control the dynamic,sustained and sequential release of drugs or cells.

关 键 词：材料 敷料 海藻酸盐 组织工程 水凝胶 创面愈合 药物传递 抗生素 细胞治疗 生长因子 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]