冠状动脉原位病变药物涂层球囊成形术后靶病变再狭窄的相关危险因素分析  

Analysis of Risk Factors Associated with Restenosis of Target Lesions After Drug Coated Balloon Angioplasty for De Novo Coronary Artery Disease

作　　者：胡振振 陶海龙[1] 孟哲[1] 王丹[1] 姬广招 HU Zhen-zhen;TAO Hai-long;MENG Zhe;WANG Dan;JI Guang-zhao(Department of Cardiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院心血管内科,河南郑州450000

出　　处：《河南医学研究》2020年第24期4426-4428,共3页Henan Medical Research

基　　金：河南省医学科技攻关计划项目(2018020032)。

摘　　要：目的探究冠状动脉原位病变药物涂层球囊(DCB)成形术后靶病变再狭窄的相关危险因素。方法纳入2016年1月至2019年1月于郑州大学第一附属医院因冠状动脉原位病变成功行DCB成形术并复查冠状动脉造影的冠心病患者134例,根据复查造影结果将患者分为再狭窄组和未再狭窄组。单因素分析采用χ^2检验或t检验比较两组的临床资料和靶病变特征,采用多因素logistic回归分析的方法分析再狭窄的相关因素。结果134例患者(再狭窄组24例,未再狭窄组110例)共计156支血管成功行DCB成形术,其中29支靶血管再狭窄,127支无再狭窄。再狭窄组患者的高血压、糖尿病及吸烟的比例高于未再狭窄组,再狭窄组靶病变长度更长,切割球囊/棘突球囊预扩张的比例低,差异有统计学意义(均P<0.05)。多因素logistic回归分析结果示,糖尿病、靶病变长度是再狭窄的独立危险因素,切割球囊/棘突球囊预扩张是其保护因素(均P<0.05)。结论糖尿病、靶病变长度是冠状动脉原位病变DCB成形术后靶病变再狭窄的独立危险因素,切割球囊/棘突球囊预扩张是其保护因素。Objective To investigate the risk factors associated with target lesion restenosis after drug coated balloon angioplasty in de novo coronary artery disease.Methods A total of 134 patients with coronary heart disease who underwent successfully drug coated balloon angioplasty for de novo coronary artery disease at the First Affiliated Hospital of Zhengzhou University from January 2016 to January 2019 and underwent coronary angiography were included.According to the results of coronary angiography,the patients were divided into restenosis group and non-restenosis group.Univariate analysis was performed with χ^2-test or t-test to compare the clinical data and target lesion characteristics between the two groups.Multivariate logistic regression analysis was used to analyze the factors associated with restenosis.Results One hundred and fifty-six vessels in 134 patients(24 in the restenosis group and 110 in the non-restenosis group)underwent successfully drug coated balloon angioplasty,of which 29 target vessels had restenosis and 127 had no restenosis.The hypertension,diabetes and smoking history of patients in restenosis group were higher than those in non-restenosis group.The target lesion length was longer and the proportion of cutting balloon/spinous process balloon pre-dilatation was lower in restenosis group(all P<0.05).The results of multivariate logistic regression analysis showed that diabetes and target lesion length were independent risk factors for restenosis,and cutting balloon/spinous process balloon predilatation was a protective factor.Conclusion Diabetes mellitus and target lesion length are independent risk factors for restenosis of de novo coronary artery disease after drug-eluting balloon angioplasty,and cutting balloon/spinous process balloon predilatation is a protective factor.

关 键 词：冠状动脉原位病变 药物涂层球囊 再狭窄 危险因素 

分 类 号：R541.6[医药卫生—心血管疾病]