感光细胞替代治疗视网膜变性疾病  

Photoreceptor cell replacement therapy for retinal degeneration diseases

作　　者：李珊珊 郭笑霄 尤冉 杨秀芬[1] 赵露[1] 陈曦[1] 王艳玲[1] Li Shanshan;Guo Xiaoxiao;You Ran;Yang Xiufen;Zhao Lu;Chen Xi;Wang Yanling(Department of Ophthalmology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院眼科,北京市100050

出　　处：《中国组织工程研究》2021年第7期1116-1121,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(81870686),项目负责人:王艳玲;北京市自然科学基金项目(7184201),项目负责人:陈曦;首都卫生发展科研专项项目(首发2018-1-2021),项目负责人:王艳玲。

摘　　要：背景:视网膜变性疾病至今仍无有效的治疗手段,其中感光细胞丢失、感光细胞功能障碍和丧失是引起视网膜退行性疾病的主要原因之一,感光细胞移植为一种有前途的细胞替代疗法,是当今研究的主要方向。目的:对感光细胞替代治疗视网膜变性疾病相关研究进展予以综述。方法:检索PubMed、CNKI、万方数据库,中文检索词为“感光细胞,视网膜,移植”,英文检索词为“photoreceptors,retina,transplantation”,通过阅读标题及摘要进行初步筛选,排除与主题相关度低的文献,最终共纳入62篇文献进行综述。结果与结论:外源性细胞作为种子细胞移植到视网膜变性环境中,用于替换晚期视网膜变性中丢失的感光细胞展现了巨大优势,为视网膜变性疾病提供了新的治疗策略。然而,至今尚未建立可供临床应用的标准化的种子细胞筛选方案,这也是在未来研究中所面临的重要挑战。BACKGROUND:There is no effective treatment for retinal degenerative diseases,among which the loss of photoreceptor cells,dysfunction and loss of photoreceptor cells are the main causes of retinal degenerative diseases.Photoreceptor cell transplantation as a promising cell replacement therapy is the main research direction today.OBJECTIVE:To review the progress of photoreceptor cell replacement in the treatment of retinal degeneration.METHODS:PubMed,CNKI and Wanfang databases were searched.The Chinese keywords were“photoreceptor cells,retina,transplantation”and the English keywords were“photoreceptors,retina,transplantation”.After preliminary screening by reading the titles and abstracts,the articles with low relevance to the subject were excluded,and a total of 62 articles were finally included for review.RESULTS AND CONCLUSION:The transplantation of exogenous cells into the retinal degeneration environment to replace the photoreceptors lost in advanced retinal degeneration has shown great advantages and provided a new therapeutic strategy for the diseases of retinal degeneration.However,standardized cell screening protocols for clinical use are still not perfect,which is an important challenge for future research.

关 键 词：干细胞 感光细胞 视网膜 变性 移植 视神经 综述 

分 类 号：R459.9[医药卫生—治疗学] R394.2[医药卫生—临床医学]