20例COVID-2019患者临床特征及血嗜酸性粒细胞与白细胞总数、淋巴细胞计数及血小板的相关性分析  

Clinical characteristics of 20 patients with COVID-2019 and the correlation among eosinophils and leukocytes,lymphocyte count and platelets

作　　者：朱孟德[1] 徐康[1] 程玉生[2] ZHU Meng-de;XU Kang;CHENG Yu-sheng(Department of Respiratory and Critical Care Medicine,1.Hefei First People's Hospital,Hefei 230061;Yijishan Hospital,Wannan Medical College,Wuhu 241000,Anhui,China)

机构地区：[1]合肥市第一人民医院呼吸与危重症医学科,安徽合肥230061 [2]皖南医学院弋矶山医院呼吸与危重症医学科,安徽芜湖241000

出　　处：《川北医学院学报》2020年第4期742-745,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨20例COVID-2019患者临床特征以及血嗜酸性粒细胞与白细胞总数、淋巴细胞计数及血小板的相关性。方法:回顾性分析2020年1月27至2020年2月26日确诊的COVID-2019患者的临床资料;根据血嗜酸性粒细胞总数将患者分为正常组和降低组,观察并对比两组患者的临床资料特征,采用Spearman相关性分析血嗜酸粒细胞与白细胞、淋巴细胞及血小板之间的相关性。结果:COVID-2019确诊病例共20例,其中男性9例,女性11例;平均年龄(37.9±12.05)岁;临床分型以轻型与普通型最多见;多存在明确流行病学史且无基础疾病;影像学表现以双侧磨玻璃阴影者最多见。血白细胞总数、淋巴细胞绝对值及血小板计数在嗜酸性粒细胞正常组和降低组两组之间存在统计学差异(P<0.05)。Spearman相关性分析研究发现血嗜酸性粒细胞计数与白细胞总数、淋巴细胞绝对数及血小板计数均呈正相关,相关系数分别为0.577(P=0.008)、0.701(P=0.001)及0.475(P=0.034)。结论:血嗜酸性粒细胞总数降低在COVID-2019患者中较多见,与血白细胞总数、淋巴细胞计数及血小板数均呈显著性正相关。对于COVID-2019患者血嗜酸性粒细胞计数减少现象需引起临床足够重视。Objective:To explore the clinical characteristics of 20 patients with COVID-2019 and the correlation between eosinophils and leukocytes,lymphocyte count and platelets.Methods:The clinical data of patients diagnosed with COVID-2019 from January 27,2020 to February 26,2020 were retrospectively analyzed.According to the total number of eosinophils,the patients were divided into two groups:normal group and reduced group.The clinical data of the two groups were observed and compared.The correlation between eosinophils,leukocytes,lymphocytes and platelets was analyzed by Spearman correlation.Results:A total of 20 patients with COVID-2019 were reviewed,including 9 males and 11 females,with an average age of(37.9±12.05)years.The clinical types were mild and normal,with clear epidemiological history,but no underlying diseases in majority.The imaging manifestations were mostly bilateral ground glass shadows.There were statistically significant differences in the total number of white blood cells,the absolute value of lymphocytes and the platelet count between the eosinophil control group and the eosinophil normal group(P<0.05).Spearman correlation analysis showed that eosinophil count was positively significantly correlated with total white blood cell count,absolute lymphocyte count and platelet count,with correlation coefficients of 0.577(P=0.008),0.701(P=0.001)and 0.475(P=0.034),respectively.Conclusion:Decreased blood eosinophil was obseved in patients with COVID-2019,which was positively correlated with the total number of white blood cells,lymphocyte count and platelet count.The change of blood eosinophil should be paid more attention in patients with COVID-2019.

关 键 词：嗜酸性粒细胞 血嗜酸性粒细胞 新型冠状病毒 肺炎 

分 类 号：R795[医药卫生—临床医学]