基于网络药理学的小承气汤治疗慢传输型便秘机制研究  

Research on the Mechanism of Xiaochengqi Decoction in the Treatment of STC Based on Network Pharmacology

作　　者：郑昊[1] 李丽英 苗德光[3] 郇靖[3] ZHENG Hao;LI Liying;MIAO Deguang;HUAN Jing(Department of Rehabilitation,Linyi People’s Hospital,Shandong Province,Linyi 276000,China;Department of Rehabilitation Medicine,Shandong Medical College,Shandong Province,Linyi 276000,China;Department of Acupuncture and Moxibustion,Linyi People’s Hospital,Shandong Province,Linyi 276000,China)

机构地区：[1]临沂市人民医院康复科,山东临沂276000 [2]山东医学高等专科学校康复医学教研室,山东临沂276000 [3]临沂市人民医院针灸科,山东临沂276000

出　　处：《中国中医药现代远程教育》2020年第15期69-71,共3页Chinese Medicine Modern Distance Education of China

基　　金：山东中医药科技发展计划项目【No.2019-0851,2017-469,2019-0861】;山东省临沂市科技发展计划项目【No.201919022】。

摘　　要：目的通过网络药理学探讨小承气汤治疗慢传输型便秘的相关作用机制。方法通过检索TCMSP提取小承气汤的有效成份及其作用靶点。检索Gene Cards数据库提取慢传输型便秘疾病靶点。运用STRING数据库构建蛋白互作网络图。结果共获得大黄主要化学成分92个、厚朴139个、枳实65个,得到23个有效活性成分和药物靶点蛋白66个,药物与慢传输型便秘共同的靶点为55个。蛋白互作网络发现MAPK8、EGFR、IL6等可能是小承气汤临床用于治疗慢传输型便秘的关键靶点。结论初步预测了小承气汤治疗STC的多成分,多靶点,多途径的特点,为进一步研究提供了方向。Objective To explore the mechanism of Xiaochengqi decoction(XCQD)on slow transit constipation(STC)by means of network pharmacology.Methods By searching in TCMSP database,the active ingredients and targets of XCQD were extracted.By searching in GeneCards database,extracted the disease targets of STC.The network of compounds-targets and disease-targets was constructed by Cytoscape,and the protein-protein interaction(PPI)network was constructed by String.Results We got a total of 92 major chemical components of Dahuang,139of Houpu,and 65 of Zhishi,a total of 23 active ingredients and 66 target proteins after removal their duplicates.There were 55 common targets between the disease and drug.The network of the protein interaction found that MAPK8,EGFR,IL6 might be the key targets of XCQD in the treatment for STC.Conclusion Based on the network of pharmacology,this study preliminarily predicted the characteristics of the multi-component,multi-target,and multi-pathway of XCQD in the treatment of STC,which provides a direction for further studies.

关 键 词：小承气汤 便秘 网络药理学 靶点 信号通路 

分 类 号：R285.5[医药卫生—中药学]