沙丁胺醇、布地奈德不同给药顺序雾化吸入治疗儿童哮喘急性发作的研究  

A Study on the Effects of Dosing Schedule of Inhaled Salbutamol and Budesonide to Treat Acute Asthma Attacks in Children

作　　者：王娴 WANG Xian(Department of Pediatrics,Central Hospital of Bao'an District Shenzhen,Shenzhen Guangdong 518102,China)

机构地区：[1]深圳市宝安区中心医院,广东深圳518102

出　　处：《湖北科技学院学报（医学版）》2020年第4期316-319,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的通过比较儿童哮喘急性发作期不同顺序氧气驱动雾化吸入沙丁胺醇、布地奈德的治疗效果,为在临床工作中选择恰当的平喘药物氧气驱动雾化吸入顺序,提供参考依据。方法选取90例儿童哮喘急性发作期的住院患儿,随机、均衡分为A、B、C共3组,每组30例。A组:沙丁胺醇与布地奈德同时加入雾化杯中氧气驱动雾化吸入;B组:先氧气驱动雾化吸入沙丁胺醇结束15min后再氧气驱动雾化吸入布地奈德;C组:先氧气驱动雾化吸入布地奈德结束15min后再氧气驱动雾化吸入沙丁胺醇。3组患儿均在氧气驱动雾化吸入沙丁胺醇、布地奈德治疗结束后15min,观察其临床疗效及肺功能指标改善情况。结果B组在咳嗽、喘息、气促、胸闷症状缓解、肺部哮鸣音减少或消失等临床疗效及肺功能指标改善方面,明显优于A、C组,差异具有统计学意义(P<0.05),而A、C两组组间比较,差异无统计学意义(P>0.05);结论先氧气驱动雾化吸入沙丁胺醇治疗结束15min后,再氧气驱动雾化吸入布地奈德的临床疗效最好,肺功能指标改善最佳,是儿童哮喘急性发作期平喘药物氧气驱动雾化吸入治疗的最佳方法。Objective By comparing the therapeutic effects of different dosing sequences of oxygen-driven salbutamol nebulization and budesonide nebulization in children with acute asthma attacks,this study provides a reference for selecting the appropriate dosing sequence of oxygen-driven anti-asthmatic nebulization in clinical work.Methods 90 children with acute asthma attacks were randomly and evenly divided into three groups:A,B and C,with 30 children in each group.Group A:Salbutamol and budesonide were added to the atomization cup and were inhaled simultaneously.Group B:Oxygen-driven salbutamol nebulization was given,followed by a 15 minutes rest.Then oxygen-driven budesonide nebulization was given.Group C:Oxygen-driven budesonide nebulization was given,followed by a 15 minutes rest.Then oxygen-driven salbutamol nebulization was given.The patients in the three groups were observed 15 minutes after the end of the treatment.The clinical efficacy and improvement of lung function index were evaluated and compared.Results The clinical efficacy of Group B was significantly better than that of Group A and Group C in the treatment of cough,wheezing,shortness of breath,chest tightness,and reduction or disappearance of lung wheezing.The difference was statistically significant(P<0.05).In terms of improvement of lung function index,Group B was statistically significant better than Group A and Group C(P<0.05).There was no statistically significant difference between Group A and Group C(P>0.05).Conclusion The treatment using oxygen-driven salbutamol nebulization followed by 15 minutes rest and then giving budesonide nebulization was shown to have the best clinical efficacy and could achieve a better improvement in lung function index.Thus,this dosing sequence should be considered as the optimal inhalation therapy for children with acute asthma attacks.

关 键 词：沙丁胺醇 布地奈德 儿童哮喘 雾化吸入 

分 类 号：R725.6[医药卫生—儿科]