五积散联合克罗米芬治疗痰湿型多囊卵巢综合征不孕症临床研究  

Clinical Observation on Wuji Powder Combined with Clomiphene in Treating Infertility Induced by Phlegm-Dampness Type Polycystic Ovary Syndrome

作　　者：张媛[1,2] 王宇吉 刘冰艺 李淑萍 ZHANG Yuan;WANG Yu-ji;LIU Bing-yi;LI Shu-ping(Changzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, 213003, China;The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China)

机构地区：[1]南京中医药大学附属常州市中医医院,江苏常州213003 [2]南京中医药大学第一临床医学院,江苏南京210023

出　　处：《南京中医药大学学报》2020年第4期444-448,共5页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省中医药科技项目(YB2017057)。

摘　　要：目的观察五积散联合克罗米芬治疗痰湿型多囊卵巢综合征不孕症的临床疗效。方法选取我院2018年2月至2018年10月就诊的80例痰湿型多囊卵巢综合征不孕症患者作为研究对象,随机分为2组,各40例,对照组予克罗米芬治疗,研究组予五积散联合克罗米芬治疗,2组均治疗3个月经周期,比较2组患者的排卵率、妊娠率、流产率、Th1和Th2细胞比例、中医证候积分的变化和临床疗效。结果治疗后研究组排卵率、妊娠率明显高于对照组(P<0.05),流产率低于对照组(P<0.05)。2组Th1细胞比例、Th1/Th2比值均降低(P<0.01),研究组优于对照组(P<0.01)。研究组中医证候积分较治疗前明显降低(P<0.01),优于对照组(P<0.01)。研究组临床疗效优于对照组(P<0.05)。结论与单用克罗米芬相比,五积散联合克罗米芬治疗痰湿型多囊卵巢综合征不孕症的临床疗效更加显著,可有效提高排卵率和妊娠率,降低流产率,改善中医临床症状,其作用机制可能与调控炎症因子水平有关。OBJECTIVE To observe the clinical effect of Wuji powder combined with clomiphene in the treatment of infertility caused by polycystic ovarian syndrome in phlegm and dampness pattern.METHODS Eighty patients with infertility caused by polycystic ovarian syndrome in phlegm and dampness pattern admitted in our hospital from February 2018 to October 2018 were enrolled as the research object.They were divided into 2 groups,40 cases of each group.The control group was treated with clomiphene,and the research group was treated with Wuji powder combined with clomiphene for 3 menstrual cycles.The ovulation rates,pregnancy rates,miscarriage rates,proportions of Th1 and Th2,traditional Chinese medicine(TCM)syndrome scores,and clinical efficacy in the two groups were compared.RESULTS After treatment,the ovulation rate and pregnancy rate in the research group were significantly higher than those in the control group(P<0.05),while the miscarriage rate was lower than the control group(P<0.05).The ratios of Th1 and Th1/Th2 of the two groups decreased(P<0.01),while the improvement of inflammation factor in the research group was better than that in the control group(P<0.01).The score of TCM syndrome in the research group after treatment was significantly lower than that before treatment(P<0.01).The research group was better than the control group(P<0.01).The clinical efficacy of the research group was better than that of the control group(P<0.05).CONCLUSION Compared with clomiphene alone,the clinical effect of Wuji powder combined with clomiphene in treating infertility caused by polycystic ovary syndrome in phlegm and dampness pattern has more significant efficacy.It can effectively increase the ovulation rate and pregnancy rate,decrease the miscarriage rate,and improve the clinical TCM symptoms.The mechanism may be related to the regulation of inflammatory factor levels.

关 键 词：多囊卵巢综合征 不孕症 五积散 克罗米芬 TH细胞 

分 类 号：R271.14[医药卫生—中医妇科学]