枸地氯雷他定片联合胎盘组织液治疗慢性荨麻疹的临床疗效观察  

Clinical effects on chronic urticaria treated with Desloratadine Citrate Disodium tablets and placental tissue fluid

作　　者：彭光玲 陈靓 李娟[2] PENG Guangling;CHEN Liang;LI Juan(Department of Dermatology,Fifth People′s Hospital of Chongqing,Chongqing 400062,China;Department of Pharmacy,Fifth People′s Hospital of Chongqing,Chongqing 400062,China)

机构地区：[1]重庆市第五人民医院皮肤性病科,重庆400062 [2]重庆市第五人民医院药剂科,重庆400062

出　　处：《检验医学与临床》2020年第17期2491-2493,共3页Laboratory Medicine and Clinic

摘　　要：目的观察枸地氯雷他定片联合胎盘组织液治疗慢性荨麻疹的临床疗效和安全性。方法以重庆市第五人民医院皮肤性病科门诊就诊的120例慢性荨麻疹患者为研究对象,随机分为试验组和对照组,每组60例。试验组予以枸地氯雷他定片联合胎盘组织液治疗,对照组仅予以枸地氯雷他定片口服。治疗8周后观察疗效及不良反应,停药4周观察复发率。结果治疗8周后两组患者症状评分不同程度下降,差异均有统计学意义(P<0.05);试验组症状评分明显低于对照组,总有效率高于对照组,差异有统计学意义(P<0.05)。停药4周后试验组复发率低于对照组,差异有统计学意义(P<0.05)。两组均无严重不良反应发生。结论枸地氯雷他定片联合胎盘组织液治疗慢性荨麻疹安全性高,疗效好,复发率低。Objective To investigate the clinical efficacy and safety of chronic urticaria treated with Desloratadine Citrate Disodium tablets and placental tissue fluid.Methods A total of 120 patients with chronic urticaria admitted to Department of Dermatology of Fifth People′s Hospital of Chongqing were enrolled in the study.The patients were randomly divided into experimental group and control group,60 cases in each group.The experimental group was given orally Desloratadine Citrate Disodium tablets and injected with placental tissue fluid,and the control group was given Desloratadine Citrate Disodium tablets.The efficacy and adverse reactions were evaluated after 8 weeks of treatment,and recurrence rate was observed after 4 weeks of withdrawal of drug.Results After 8 weeks of treatment,the scores of symptoms decreased in both groups and that in the experimental group were significantly lower than that in the control group,and the differences were statistically significant(P<0.05).The total effective rate was higher than that in the control group,and the difference was statistically significant(P<0.05).The recurrence rate in the experimental group was lower than that in the control group after 4 weeks of withdrawal of drug,and the differences were statistically significant(P<0.05).No serious reactions were observed in both groups.Conclusion Desloratadine Citrate Disodium tablets combined with placental tissue fluid is safe,effective and has low recurrence rate in the treatment of chronic urticaria.

关 键 词：慢性荨麻疹 胎盘组织液 枸地氯雷他定 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]