血清PCT、VitD联合检测对儿童细菌性血流感染的诊断价值  

Value of combined detection of procalcitonin and Vitamin D in diagnosis of bacterial bloodstream infections

作　　者：安娜[1] 李冰瑶 罗军[1] 陈曦[1] 罗立梅[1] AN Na;LI Bingyao;LUO Jun;CHEN Xi;LUO Limei(Department of Clinical Laboratory,Mianyang Central Hospital,Mianyang,Sichuan 621000,China)

机构地区：[1]四川省绵阳市中心医院检验科,四川绵阳621000

出　　处：《检验医学与临床》2020年第17期2494-2496,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨降钙素原(PCT)与维生素D(VitD)联合检测对儿童细菌性血流感染的诊断价值。方法对86例血培养阳性患儿(阳性组)和86例非感染性疾病患儿(对照组)进行PCT和VitD检测,采用电化学发光法检测PCT和VitD水平。结果阳性组PCT水平高于对照组,而VitD水平低于对照组,差异有统计学意义(P<0.05)。阳性组中,PCT的灵敏度和特异度分别为65.12%和76.74%,VitD的灵敏度和特异度分别是63.95%和52.33%,PCT与VitD联合检测的灵敏度为83.72%,特异度为82.55%。PCT、VitD及联合检测诊断血流感染的受试者工作特征(ROC)曲线下面积分别为0.734、0.664、0.757。VitD水平与PCT呈负相关(r=-0.275,P<0.001)。结论VitD可用于诊断儿童细菌性血流感染,且与PCT联合检测可提高血流感染的检出率,具有一定的诊断价值。Objective To investigate the value of combined detection of procalcitonin(PCT)and Vitamin D(VitD)in bacterial bloodstream infections(BSI)in children.Methods PCT and VitD were detected in 86 children with positive blood culture(positive group)and 86 children with non-infectious diseases(control group)by the electrochemical luminescence.Results The PCT level in the positive group was higher than that in the control group,while the VitD level was lower than that in the control group,and the differences were statistically significant(P<0.05).The sensitivity and the specificity of PCT in positive group were 65.12%and 76.74%,respectively,the sensitivity and the specificity of VitD were 63.95%and 52.33%respectively,and the sensitivity and the specificity of PCT+VitD combined detection were 83.72%and 82.55%.The area under the receiver operating characteristic(ROC)curve of PCT,VitD and combined detection for diagnosing BSI were 0.734,0.664 and 0.757,respectively.VitD level was negatively correlated with PCT level(r=-0.275,P<0.001).Conclusion VitD can be used to diagnose bacterial BSI,and the combined detection with PCT can improve the detection efficiency of BSI in children,which has certain diagnostic value.

关 键 词：降钙素原 维生素D 血流感染 感染性疾病 

分 类 号：R446.5[医药卫生—诊断学] R446.6[医药卫生—临床医学]