益气复律汤对中老年室性心律失常阴虚火旺证患者的临床疗效及BNP、NO水平的影响  

Study on the effect of Yiqifulv Decoction on the clinical effect and BNP,NO in the middle-aged and elder patients with ventricular arrhythmia and yin deficiency and fire hyperactivity

作　　者：彭宇 文中华 PENG Yu;WEN Zhonghua(Department of Pharmacy,Liaoning Provincial Health Industry Group Iron Coal General Hospital,Tieling,Liaoning 112700,China;Department of Circular Medicine,Liaoning Provincial Health Industry Group Iron Coal General Hospital,Tieling,Liaoning 112700,China)

机构地区：[1]辽宁省健康产业集团铁煤总医院药剂科,辽宁铁岭112700 [2]辽宁省健康产业集团铁煤总医院循环内科,辽宁铁岭112700

出　　处：《检验医学与临床》2020年第17期2524-2527,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨益气复律汤对中老年室性心律失常阴虚火旺证患者的临床疗效及B型钠尿肽(BNP)、一氧化氮(NO)水平的影响。方法选取2017年8月至2019年8月于该院就诊的98例中老年室性心律失常阴虚火旺证患者,采用随机数表法分为对照组和观察组,每组49例。对照组给予胺碘酮治疗,观察组在此基础上给予益气复律汤治疗。比较两组患者治疗效果,记录治疗前、治疗后患者心电图PR间期、QRS时限、BNP、NO、血清心肌肌钙蛋白I(cTnI)水平、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)变化及治疗期间不良反应发生率。结果治疗后,观察组总有效率高于对照组(93.88%vs.77.55%),差异有统计学意义(P<0.05)。治疗后,两组患者心电图PR间期及QRS时限均有升高,观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者BNP、NO、cTnI水平均有降低,且观察组BNP、NO、cTnI水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者LVEDD均有降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者LVEF均有升高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者均有出现皮疹、恶心呕吐、腹泻等不良反应,观察组不良反应发生率为8.16%,低于对照组的24.49%,差异有统计学意义(P<0.05)。结论胺碘酮联合益气复律汤治疗中老年室性心律失常阴虚火旺证患者效果显著,可改善患者心电图及心功能,且具有良好的安全性,值得临床推广使用。Objective To explore the effect of Yiqifulvu Decoction on the clinical improvement and the levels of B-type natriuretic peptide(BNP)and nitric oxide(NO)in the middle-aged and elderly patients with ventricular arrhythmia and yin deficiency and fire excess.Methods A total of 98 middle-aged and elderly patients with ventricular arrhythmia and yin deficiency and fire hyperactivity syndrome admitted to the hospital from August 2017 to August 2019 were selected and divided into observation group and control group by random number table method,49 cases in each group.The control group was treated with amiodarone,and the observation group was treated with Yiqifulvu Decoction on basis of control group.The treatment effects of the two groups were compared.The changes of PR period and QRS duration of ECG,BNP,NO,serum cardiac troponin I(cTnI),end diastolic diameter of left ventricle(LVEDD),left ventricular ejection fraction(LVEF)before and after treatment and the incidence of adverse reactions during treatment were recorded.Results After treatment,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the PR period and QRS duration of ECG in the two groups were increased,and the values in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of BNP,NO and cTnI in the two groups were decreased,and the above indexes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the LVEDD in the two groups were decreased,and the values in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the LVEF in the two groups were increased,and the LVEF in the observation group was higher than that in the control group,and the differences were statistically significant(P<

关 键 词：益气复律汤 心律失常 B型钠尿肽 

分 类 号：R541.7[医药卫生—心血管疾病]