咪唑型离子液体/苯两相体系下不对称催化氢化合成手性泛内酯  

Asymmetric hydrogenation for synthesis of chiral lactones in imidazolium ionic liquid/benzene two-phase system

作　　者：朱琳 崔菲菲 金欣[1] ZHU Lin;CUI Feifei;JIN Xin(Department of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]青岛科技大学化工学院,山东青岛266042

出　　处：《化工科技》2020年第4期19-22,共4页Science & Technology in Chemical Industry

基　　金：国家自然科学基金项目(21576144);山东省自然科学基金项目(ZR2014BM009);青岛市基础研究计划项目[12-1-4-3-(6)-jch]。

摘　　要：以咪唑型离子液体1-乙基-3-甲基咪唑四氟硼酸盐([EMIM]BF4)、1-丁基-3-甲基咪唑四氟硼酸盐(BF4)、1-丁基-3-甲基咪唑双三氟甲磺酰亚胺盐(Tf2N)与甲苯为溶剂,将膦配体Ⅰ~Ⅴ应用于手性泛内酯的不对称加氢过程中,配体Ⅲ在[EMIM]BF4/苯两相体系下获得了相对较高催化活性和对映选择性。该手性催化剂循环5次仍能保持较高的催化活性和对映选择性。With imidazolium ionic liquid 1-ethyl-3-methyimidazolium tetrafluoroborate([EMIM]BF4),1-butyl-3-methylimidazolium tetrafluoroborate(BF4),1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide(Tf2N)and toluene as solvents,ligand I^V was applied to asymmetric hydrogenation of chiral pantolactone.LigandⅢwas proved to achieve relatively high catalytic activity and enantioselectivity in the[EMIM]BF4/benzene two-phase system.The high catalytic activity and enantioselectivity of the chiral catalyst could be maintained after 5 cycles.

关 键 词：咪唑离子液体 手性泛内酯 不对称加氢 

分 类 号：O645.1[理学—物理化学]