银杏达莫注射液在三种大输液中的稳定性考察  

Stability of Ginkgo Leaf Extract and Dipyridamole Injection in Three Kinds of Infusion

作　　者：刘秀珍[1] 刘建军[1] 徐文 LIU Xiuzhen;LIU Jianjun;XU Wen(Dept. of Pharmacy, the Second People’s Hospital of Hefei, Anhui Hefei 230000, China;Dept. of Neurology Internal Medicine, the First Affiliated Hospital of University of Science and Technology of China, Anhui Hefei 230000, China)

机构地区：[1]合肥市第二人民医院药剂科,安徽合肥230000 [2]中国科学技术大学附属第一医院神经内科,安徽合肥230000

出　　处：《中国医院用药评价与分析》2020年第7期792-795,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：安徽省自然科学基金青年项目(No.1808085QH244)。

摘　　要：目的:探讨银杏达莫注射液调配后成品输液8 h内的物理性质稳定情况,为其临床安全使用提供参考。方法:依据药品说明书和临床常用剂量对银杏达莫注射液进行调配,考察放置0、2、4及8 h成品输液的外观性状、pH、微粒及渗透压等物理性质。结果:银杏达莫注射液在0.9%氯化钠注射液中微粒最小且持续稳定,在5%/10%葡萄糖注射液中微粒较大且不稳定。渗透压方面,该药在10%葡萄糖注射液中渗透压最大,在5%葡萄糖注射液和0.9%氯化钠注射液稀释后的成品输液渗透压更接近人体渗透压。该药在3种大输液中pH变化趋势基本相同,各时间点pH符合要求。该药调配后2 h物理性质稳定,2 h后物理性质急剧改变。结论:临床使用银杏达莫注射液时,为减少不良事件的发生,建议选择0.9%氯化钠注射液作为稀释溶剂,如果患者有电解质方面摄入要求,建议改用5%葡萄糖注射液作为稀释溶剂;而10%葡萄糖注射液不推荐作为溶剂使用。用药时限方面,建议药品调配后2 h内用完。OBJECTIVE:To probe into the physical stability of finished infusion of ginkgo leaf extract and dipyridamole injection within 8 h,so as to provide reference for clinical safety and rational use.METHODS:According to the drug instructions and clinical dosage,ginkgo leaf extract and dipyridamole injection was prepared,and physical properties such as appearance,pH,particles and osmotic pressure of finished infusion were investigated after 0,2,4 and 8 h.RESULTS:Ginkgo leaf extract and dipyridamole injection was the smallest and stable in 0.9%sodium chloride injection.The particles were large and unstable in 5%/10%glucose injection.In terms of osmotic pressure,the osmotic pressure of this drug was the largest in 10%glucose injection,and the osmotic pressure of finished infusion diluted with 5%glucose injection and 0.9%sodium chloride injection was closer to that of human body.The changes of the pH in three kinds of infusions were basically the same,and the pH at each time point met the requirements.The physical properties were stable within 2 h after the preparation,and changed sharply 2 h after preparation.CONCLUSIONS:In the clinical use of ginkgo leaf extract and dipyridamole injection,0.9%sodium chloride injection is recommended as the diluent for the reduction of adverse events.If the patient has electrolyte requirements,it is recommended to use 5%glucose injection as dilution.Yet 10%glucose injection is not recommended as the solvent.In terms of the time limit for administration,it is recommended to use up within 2 h after drug preparation.

关 键 词：银杏达莫注射液 成品输液 物理性质 

分 类 号：R972[医药卫生—药品]