656例药物性肝损伤病例的回顾性分析  

Retrospective Analysis of 656 Patients with Drug-induced Liver Injury

作　　者：程遥[1] 王景红[1] 夏坤[1] 蒋季明 周惠萍 CHENG Yao;WANG Jinghong;XIA Kun;JIANG Jiming;ZHOU Huiping(Dept. of Pharmacy, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China)

机构地区：[1]中国中医科学院望京医院药学部,北京100102

出　　处：《中国医院用药评价与分析》2020年第7期885-888,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨导致药物性肝损伤(drug-induced liver injury,DILI)的药物种类、特点,为临床合理用药提供参考。方法:收集2010年1月至2019年6月中国中医科学院望京医院收治的656例DILI患者,对患者的临床资料进行统计分析。结果:656例DILI患者中,男性患者占59.0%(387例),女性患者占41.0%(269例),男性多于女性;发生DILI患者的原发疾病中,病例数排序居前5位的分别为感染性疾病、胃肠病、心血管疾病、皮肤病及风湿病;中西药联合应用导致DILI的占91.5%(600例),单独使用西药导致的DILI占8.5%(56例),涉及中草药、中成药、抗感染药、抗肿瘤药、激素类药物、心血管系统用药以及消化系统用药等。结论:本研究中,DILI在男性患者中的发病率较高,中草药及中成药、抗感染药、抗肿瘤药、激素类药物、心血管系统用药和非甾体抗炎药均会引起DILI,应引起临床足够重视,防止不良反应的发生。OBJECTIVE:To probe into the categories and characteristics of drugs leading to drug-induced liver injury(DILI),so as to provide references for clinical rational drug use.METHODS:Totally 656 patients with DILI admitted into Wangjing Hospital,China Academy of Chinese Medical Sciences from Jan.2010 to Jun.2019 were extracted.Statistical analysis was performed on clinical data of patients.RESULTS:Of the 656 patients with DILI,59.0%(387 cases)was male,41.0%(269 cases)was female,and more male than female.Among the primary diseases of DILI,infectious diseases,gastrointestinal diseases,cardiovascular diseases,skin diseases and rheumatism ranked the top 5.The drug combination of Chinese and Western medicine resulted in 91.5%(600 cases)of DILI,and 8.5%(56 cases)of DILI caused by Western medicine alone,including Chinese herbal medicine,Chinese patent medicine,anti-infective drugs,anti-tumor drugs,hormone drugs,cardiovascular drugs and digestive drugs.CONCLUSIONS:In this study,the incidence of DILI in male patients is relatively high.Chinese herbal medicine and Chinese patent medicine,anti-infective drugs,anti-tumor drugs,hormonal drugs,cardiovascular drugs and digestive drugs can cause DILI,and clinical attention should be paid to prevent the occurrence of adverse drug reactions.

关 键 词：药物性肝损伤 回顾性分析 合理用药 

分 类 号：R969.3[医药卫生—药理学]