An integrated spectroscopic strategy to trace the geographical origins of emblic medicines: Application for the quality assessment of natural medicines  

作　　者：Luming Qi Furong Zhong Yang Chen Shengnan Mao Zhuyun Yan Yuntong Ma 

机构地区：[1]State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China [2]School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China

出　　处：《Journal of Pharmaceutical Analysis》2020年第4期356-364,共9页药物分析学报（英文版）

基　　金：This work is financially supported by the National Wild Plant Germplasm Resources Infrastructure which is the follow-up work of a project called Standardization and Community for the Collection and Preservation of Important Wild Plant Germplasm Resources(2005DKA21006).

摘　　要：Emblic medicine is a popular natural source in the world due to its outstanding healthcare and therapeutic functions.Our preliminary results indicated that the quality of emblic medicines might have an apparent regional variation.A rapid and effective geographical traceability system has not been designed yet.To trace the geographical origins so that their quality can be controlled,an integrated spectroscopic strategy including spectral pretreatment,outlier diagnosis,feature selection,data fusion,and machine learning algorithm was proposed.A featured data matrix(245
220)was successfully generated,and a carefully adjusted RF machine learning algorithm was utilized to develop the geographical traceability model.The results demonstrate that the proposed strategy is effective and can be generalized.Sensitivity(SEN),specificity(SPE)and accuracy(ACC)of 97.65%,99.85%and 97.63%for the calibrated set,as well as 100.00%predictive efficiency,were obtained using this spectroscopic analysis strategy.Our study has created an integrated analysis process for multiple spectral data,which can achieve a rapid,nondestructive and green quality detection for emblic medicines originating from seventeen geographical origins.

关 键 词：Emblic medicine Quality assessment Geographical traceability Spectroscopic analysis process 

分 类 号：R284[医药卫生—中药学]