肺结核合并糖尿病不同抗结核治疗方案效果分析  

An analysis of the efficacy of different anti-tuberculosis therapies for pulmonary tuberculosis complicated with diabetes mellitus

作　　者：邵根霞 甄利波 沈莉莉[1] 金露青 魏强[1] SHAO Genxia;ZHEN Libo;SHEN Lili;JIN Luqing;WEI Qiang(Internal Medicine-Tuberculosis,Zhejiang Integrated Traditional and Western Medicine Hospital(Hangzhou Red Cross Hospital),Hangzhou310003,China)

机构地区：[1]浙江省中西医结合医院(杭州市红十字会医院)结核内科,浙江杭州310003

出　　处：《中国现代医生》2020年第21期19-22,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2018KY141)。

摘　　要：目的探讨肺结核合并糖尿病不同抗结核方案的临床效果。方法选择2018年1~12月在我院诊断治疗的肺结核合并糖尿病患者60例为研究对象,随机分为观察组与对照组,各30例。对照组采用3HREZ/9HR抗结核治疗,观察组采用3HREZLfx/9HR抗结核治疗。比较两组治疗后痰菌转阴率、病灶吸收率、空洞闭合情况以及不良反应情况。结果(1)治疗1个月、3个月,观察组累计痰菌转阴率显著高于对照组,差异有统计学意义(P<0.05)。治疗后9个月,两组累计痰菌转阴率均达到100.0%。(2)秩和检验显示,观察组在治疗3个月、治疗12个月时病灶显著吸收率高于对照组,差异有统计学意义(P<0.05);χ^2检验显示,观察组在治疗6个月时病灶总吸收率高于对照组,差异有统计学意义(P<0.05)。(3)秩和检验显示,在治疗3个月、6个月时,观察组空洞闭合率显著高于对照组,差异有统计学意义(P<0.05);治疗3个月、6个月时,观察组空洞总改善率显著高于对照组,差异有统计学意义(P<0.05)。(4)观察组不良反应发生率高于对照组,但两组比较差异无统计学意义(P>0.05)。结论3HREZLfx/9HR抗结核方案治疗肺结核合并糖尿病患者可促进痰菌转阴,促使病灶吸收、空洞闭合,并且不显著增加不良反应发生率。Objective To explore the clinical efficacy of different anti-tuberculosis therapies for pulmonary tuberculosis(PT)complicated with diabetes mellitus(DM).Methods 60 patients diagnosed with PT complicated with DM and treated in our hospital from January to December 2018 were selected as the subjects of research and randomly divided into the observation group and the control group,with 30 patients in each group.The control group received 3HREZ/9HR anti-tuberculosis treatment,while the observation group received 3HREZLfx/9HR anti-tuberculosis treatment.The sputum negative conversion rate,lesion absorption rate,cavity closure and adverse reactions(ADRs)after treatment were compared between the two groups.Results(1)The cumulative sputum negative conversion rate of the observation group was significantly higher than that of the control group after 1 month and 3 months of treatment,with statistically significant difference(P<0.05).After 9 months of treatment,the cumulative sputum negative conversion rate of both groups reached 100.0%.(2)Rank sum test showed that the lesion absorption rate of the observation group was significantly higher than that in the control group after 3 months and 12 months of treatment,with statistically significant differences(P<0.05).Chi-square test showed that the total lesion absorption rate of the observation group was higher than that of the control group after 6 months of treatment,with statistically significant difference(P<0.05).(3)Rank sum test showed that the cavity closure rate of the observation group was significantly higher than that of the control group after 3 months and 6 months of treatment,with statistically significant differences(P<0.05).The total cavity restoration rate of the observation group was significantly higher than that of the control group after 3 months and 6 months of treatment,with statistically significant differences(P<0.05).(4)The incidence of ADRs in the observation group was higher than that in the control group,but there was no statistically significant di

关 键 词：肺结核 糖尿病 抗结核治疗 左氧氟沙星 

分 类 号：R521[医药卫生—内科学]