高血压患者低血容量状态下常规服用降压药导致严重后果3例报告  

The Serious Consequences Caused by Taking Antihypertensive Drugs Routinely in Patients with Hypertension in Hypovolemia State: A Report of Three Cases

作　　者：陈旭 朱华 顾翔 徐文俊 CHEN Xu;ZHU Hua;GU Xiang;XU Wenjun(College of Pharmacy,Dalian Medical University,Dalian,Liaoning 116044,China;Department of Pharmacy,Northern Jiangsu People's Hospital,Yangzhou,Jiangsu 225001,China;Department of Cardiology,Northern Jiangsu People's Hospital,Yangzhou,Jiangsu 225001,China)

机构地区：[1]大连医科大学药学院,大连116044 [2]苏北人民医院药学部,扬州225001 [3]苏北人民医院心血管内科,扬州225001

出　　处：《药学与临床研究》2020年第4期306-308,共3页Pharmaceutical and Clinical Research

基　　金：江苏省科技厅重大临床专项(BL2013022)。

摘　　要：对3例在低血容量状态下仍常规服用降压药导致低血容量性休克及急性肾功能损伤的高血压患者资料作回顾性分析。例1在腹泻呕吐期间常规服用降压药缬沙坦,入院时血压78/46 mmHg,肌酐明显高于正常值,少尿。例2在腹泻期间常规服用降压药缬沙坦、苯磺酸左旋氨氯地平片,入院时血压80/50 mmHg,少尿。例3腹泻伴呕吐期间常规服用苯磺酸氨氯地平,少尿,肌酐异常增加。3例均给予抗感染保护脏器、维持水电解质平衡处理。例1因多器官衰竭,要求自动出院,另2例症状好转出院。应加强对高血压患者用药教育,注意血压的监测和根据血压及时调整药物剂量。预防人体失水时,降压药品引起的严重后果的发生,促进降压药的合理使用。The data of three hypertensive patients with hypovolemic shock and acute renal function injury caused by routine antihypertensive drugs under hypovolemic condition were analyzed retrospectively.Case #1: the patient took the antihypertensive drug valsartan routinely during diarrhea and vomiting. The blood pressure was 78/46 mmHg on admission, and the creatinine level was significantly higher than normal, with oliguria. Case #2: the patient routinely took antihypertensive valsartan and levamlodipine benzenesulfonate tablets during diarrhea. The blood pressure was 80/50 mmHg on admission, with oliguria. Case #3: the patients with diarrhea and vomiting routinely took antihypertensive drug amlodipine besylate, by oliguria and abnormal high creatinine level occured. All the three cases were treated with anti-infection,and to protect organ and maintain water-electrolyte balance. One patient was automatically discharged because of multiple organ failure. The other two patients were discharged with improved symptoms. The medication education for patients with hypertension should be strengthened, and attention should be paid to the monitoring of blood pressure and the timely adjustment of drug dosages based on blood pressure, so as to prevent serious consequences caused by antihypertensive drugs when the body loses water, and promote the reasonable application of antihypertensive drugs.

关 键 词：低血容量状态 降压药 低血容量性休克 急性肾衰竭 防治 

分 类 号：R969.3[医药卫生—药理学]