CT与血清sCC-Ag、CYFRA21-1联合鉴别宫颈鳞癌腹膜后淋巴结转移的价值  

Value of CT combined with Serum sCCAg and CYFRA21-1 in the Differential Diagnosis of Retroperitoneal Lymph Node Metastasis of Cervical Squamous Cell Carcinoma

作　　者：任伟 黄璇 REN Wei;HUANG Xuan(Department of Radiology,Jingzhou Hospital of Traditional Chinese Medicine,Jingzhou 434000,Hubei Province,China)

机构地区：[1]荆州市中医医院放射科,湖北荆州434000 [2]湖北省妇幼保健院妇产科,湖北武汉430074

出　　处：《中国CT和MRI杂志》2020年第10期108-111,共4页Chinese Journal of CT and MRI

摘　　要：目的探讨CT与血清鳞状细胞癌抗原(sCC-Ag)、细胞角蛋白19片段抗原21-1(CYFRA21-1)联合鉴别宫颈鳞癌腹膜后淋巴转移的价值。方法选取2016年5月至2018年5月我院妇科收治的130例宫颈鳞癌患者为研究对象,均经术前宫颈组织活检及术后病理检查确诊,术前均行螺旋CT检查,并测定血清sCC-Ag、CYFRA21-1水平,分析三者联合诊断腹膜后淋巴转移的价值。结果术后病理结果显示,130例宫颈鳞癌患者中腹膜后淋巴结转移34例,未转移96例;CT诊断腹膜后淋巴结转移的灵敏度、特异度、准确率分别为70.59%、72.92%、72.31%;血清sCC-Ag水平诊断腹膜后淋巴结转移的灵敏度、特异度、准确率分别为67.65%、75.00%、73.08%;血清CYFRA21-1水平诊断腹膜后淋巴结转移的灵敏度、特异度、准确率分别为58.82%、72.92%、69.23%;三者联合诊断腹膜后淋巴结转移的灵敏度、特异度、准确率分别为85.29%、69.79%、73.85%;血清sCCAg水平诊断腹膜后淋巴结转移的特异度最高,三者联合诊断腹膜后淋巴结转移的灵敏度最高。结论宫颈鳞癌患者术前血清sCC-Ag异常升高预示着可能存在腹膜后淋巴转移,CT与血清sCC-Ag、CYFRA21-1水平联合诊断宫颈鳞癌腹膜后淋巴转移可提高诊断灵敏度,为临床个性化治疗提高参考依据。Objective To explore the value of CT combined with serum squamous cell carcinoma antigen(sCC-Ag)and cytokeratin 19 fragment antigen 21-1(CYFRA21-1)in the differential diagnosis of retroperitoneal lymph node metastasis of cervical squamous cell carcinoma.Methods A total of 130 patients with cervical squamous cell carcinoma admitted to gynecology department of our hospital from May 2016 to May 2018 were selected for the study.All patients were confirmed by preoperative cervical biopsy and postoperative pathological examination.All patients were spiral CT examination before operation.Serum sCC-Ag and CYFRA21-1 levels were measured,and the value of combined diagnosis of retroperitoneal lymph node metastasis was analyzed.Results The postoperative pathological results showed that there were 34 cases of retroperitoneal lymph node metastasis among 96 cases of cervical squamous cell carcinoma,and there were 96 cases without metastasis.The sensitivity,specificity and accuracy rate of CT diagnosis of retroperitoneal lymph node metastasis were 70.59%,72.92%and 72.31%respectively.The sensitivity,specificity and accuracy rate of serum sCC-Ag level in the diagnosis of retroperitoneal lymph node metastasis were 67.65%,75.00%and 73.08%respectively.The sensitivity,specificity and accuracy rate of serum CYFRA21-1 in the diagnosis of retroperitoneal lymph node metastasis were 58.82%,72.92%and 69.23%.The sensitivity,specificity and accuracy rate of combined diagnosis of retroperitoneal lymph node metastasis were 85.29%,69.79%and 73.85%respectively.The specificity was the highest by serum sCC-Ag level in the diagnosis of retroperitoneal lymph node metastasis,and the sensitivity was the highest in the three combined diagnosis of retroperitoneal lymph node metastasis.Conclusion The abnormal increase of serum sCC-Ag in patients with cervical squamous cell carcinoma indicates that there may be retroperitoneal lymph node metastasis.CT combined with serum sCC-Ag and CYFRA21-1 levels can improve the diagnostic sensitivity and provide the ref

关 键 词：CT 鳞状细胞癌抗原 细胞角蛋白19片段抗原21-1 宫颈鳞癌 腹膜后淋巴转移 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.492[医药卫生—诊断学]