螺旋CT多期扫描联合血清STAT1 、DKK-1诊断早期胃癌的临床价值  

Clinical Value of Multi-stage Helical CT Scanning Combined with Serum STAT1 and DKK-1 in the Early Detection of Gastric Cancer

作　　者：符萧泓 邱丽莉 FU Xiao-hong;QIU Li-li(Department of Radiology,The Third People’s Hospital,Haikou 571100,Hainan Province,China)

机构地区：[1]海口市第三人民医院放射科 [2]海南省医学院第二附属医院检验科,海南海口571100

出　　处：《中国CT和MRI杂志》2020年第10期128-131,共4页Chinese Journal of CT and MRI

摘　　要：目的探究螺旋CT多期扫描联合血清信号传导及转录激活因子1(STAT1)、Dickkopf-1(DKK-1)检测在胃癌早期诊断中的价值。方法选取2015年8月至2017年8月来我院就诊并且经胃镜组织活检确诊为胃癌的患者60例作为胃癌组,同时选取同期进行治疗的慢性胃炎组患者60例作为慢性胃炎组,健康人群60例作为健康对照组。分析螺旋CT、STAT1诊断、DKK-1诊断及其联合诊断在胃癌早期诊断中的价值。结果三组患者的DKK-1和STAT1表达水平差别具有统计学意义(P=0.000),且胃癌组DKK-1水平显著高于慢性胃炎组和健康对照组(P<0.05),STAT1水平显著低于慢性胃炎组和健康对照组(P<0.05);诊断效能结果显示,螺旋CT诊断的灵敏度为83.3%,特异度为67.8%;DKK1诊断的灵敏度为65.0%,特异度为70.0%;STAT1诊断的灵敏度为66.7%,特异度为69.2%;螺旋CT多期扫描联合DKK-1、STAT1检测,灵敏度为91.7%,特异度为65.8%,灵敏度高于单一指标诊断;三者联合诊断的曲线下面积为0.869,均大于单一指标诊断组(P<0.05)。结论螺旋CT联合血清STAT1和DKK-1检测,有助于提高早期胃癌诊断的准确度,弥补早期胃癌CT征象不明显而引起的漏诊。Objective To explore the value of multi-stage helical CT scanning combined with serum STAT1 and DKK-1 in detection of early gastric cancer.Method A total of 60 patients with gastric cancer,60 patients with chronic gastritis and 60 cases of healthy patients were selected from Aug 2015 to Aug 2017 in our hospital.The diagnosis value of spiral CT,STAT1,DKK-1 and their combination in detection of the early gastric cancer were evaluated.Results The expression of DKK-1 and STAT1 were significant difference in the three groups(P<0.05),and the level of DKK-1 in the gastric cancer group was higher than that in chronic gastritis group and health population(P<0.05).While the level of STAT1 in the gastric cancer group was lower than that in the other two groups(P<0.05);ROC results showed that the sensitivity and specificity for multi-stage helical CT scanning were 83.3%and 67.8%,for DKK-1 were 65.0%and 70.0%,and for STAT1 were 66.7%and 69.2%.The multi-stage spiral CT scan combined with DKK-1 and STAT1 detection displayed the highest sensitivity than any of the signle diagnosis with sensitivity and specificity as 91.7%and 65.8%.Conclusion Helical CT combined with serum STAT1 and DKK-1 detection helps to improve the accuracy of early gastric cancer diagnosis and make up for the missed diagnosis caused by the inconspicuous CT signs of early gastric cancer.

关 键 词：螺旋CT多期扫描 血清信号传导及转录激活因子1 DICKKOPF-1 胃癌 

分 类 号：R445[医药卫生—影像医学与核医学]