62株临床分离布鲁氏菌对四种常用抗生素药物敏感性实验  

Sensitivity Test of 62 Strains of Brucella Isolated from Clinical to Four Common Antibiotics

作　　者：梁英风[1] 吴金英[1] 刘岩[2] 伊茂礼[1] 周志美 LIANG Ying-feng;WU Jin-ying;LIU Yan;YI Mao-li;ZHOU Zhi-mei(Department of Clinical Laboratory,Yuhuangding Hospital,Shandong Yantai 264000,China;Department of Infectious Disease,Yuhuangding Hospital,Shandong Yantai 264000,China)

机构地区：[1]烟台毓璜顶医院检验科,山东烟台264000 [2]烟台毓璜顶医院感染科,山东烟台264000

出　　处：《现代检验医学杂志》2020年第4期116-117,129,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探究马耳他布鲁氏菌对临床常用的4种抗生素的敏感性,为临床合理用药提供数据支持。方法通过E-test方法对2015~2018年该院微生物室血培养分离出的62株马耳他布鲁氏菌进行庆大霉素、利福平、复方新诺明和多西环素四种常用抗生素的感性分析。结果该次试验中62株布鲁氏菌对庆大霉素敏感率是100%,MIC50与MIC90均为0.75μg/ml;利福平MIC50和MIC90分别为0.75μg/ml和2μg/ml;复方新诺明敏感率是0%,MIC50和MIC90分别是8μg/ml和16μg/ml;多西环素敏感率是82.1%,MIC50和MIC90分别为16μg/ml和32μg/ml。结论该次实验中用到的药物基本覆盖了治疗布鲁氏菌病的常用药,为临床实行个体化治疗提供有价值的依据和帮助。Objective To explore the antibiotic sentitive to four antimicrobial agents of Brucella melitensis and provide data support for clinical rational drug use.Methods E-test was used to detect the drug susceptivity of gentamycin,rifampicin,sulfamethoxzole-trimethoprim and doxycycline to 62 Brucella strains isolated from 2015 to 2018.Results The drug sensitivity results of 62 Brucella strains in this experiment showed that all isolates were susceptible to gentamycin,82.1%of the Brucella isolates were susceptible to doxycycline and all isolates were resistant to sulfamethoxzole-trimethoprim.The MIC50 of gentamicin,rifampicin,sulfamethoxzole-trimethoprim,and doxycycline were 0.75,0.75,8 and 16μg/ml,and MIC90 were 0.75,2,16 and 32μg/ml respectively.Conclusion The drugs used in this experiment cover common drugs for treating Brcella.It can prvide vaiuable basis and help for clinical individualized treatment.

关 键 词：布鲁氏菌 布鲁氏菌病 耐药性 最小抑菌浓度 

分 类 号：R378.5[医药卫生—病原生物学] R446.5[医药卫生—基础医学]