慢性前列腺炎合并不育患者AsAb与精液参数及解脲支原体感染的关系  

Relationship between semen parameters,Ureaplasma Urealyticum infection and AsAb in infertile patients with chronic prostatitis

作　　者：郁兆存 黄华生 杨昌俊 方钟进 陈早庆 Yu Zhaocun;Huang Huasheng;Yang Changjun;Fang Zhongjin;Chen Zaoqin(Dongguan Houjie Affiliated Hospital,Guangdong Medical University,Dongguan 523945)

机构地区：[1]广东医科大学附属东莞市厚街医院,广东东莞523945

出　　处：《中国男科学杂志》2020年第4期46-49,共4页Chinese Journal of Andrology

基　　金：广东省东莞市科技局课题(项目编号:201010515000148)。

摘　　要：目的探讨慢性前列腺炎合并不育患者血清抗精子抗体与精液参数及解脲支原体(UU)感染的关系。方法选取2017年8月至2018年10月在我院接受治疗伴有不育的CP患者83例作为观察组,选取同期在我院接受治疗生育功能正常的CP患者65例作为对照组;采集患者精液进行UU检测,并采用酶联免疫吸附法(ELISA)检测两组AsAb水平,并比较两组的精液参数,进一步分观察组AsAb阳性、阴性患者及对照组间精液参数。结果观察组AsAb阳性率、UU阳性率、T-Ig均显著高于对照组,差异有统计学意义(P<0.01);观察组中AsAb阳性者的UU感染率明显高于同组AsAb阴性者,差异有统计学意义(P<0.01);观察组的精子密度、精子活率、a级精子、(a+b)级精子均显著低于对照组,精子畸形率显著高于对照组,差异有统计学意义(P<0.01);观察组AsAb阳性者的精液参数均显著低于观察组AsAb阴性者及对照组,差异均有统计学意义(P<0.05);观察组AsAb阳性并UU感染者的各精液参数明显差于观察组AsAb阳性无UU感染者及对照组,差异均有统计学意义(P<0.01)。结论 CP不育患者体内的AsAb阳性率明显高于生育正常的CP患者,而AsAb阳性并UU感染CP不育患者的精液参数水平明显低于正常水平,提示UU感染可能为引发男性不育的原因。Objective To investigate the relationship between serum antisperm antibodies and semen parameters and UU infection in patients with chronic prostatitis and infertility. Methods A total of 83 CP patients with infertility who received treatment in our hospital from August 2017 to October 2018 were selected as the observation group, and 65 CP patients with normal fertility who received treatment in our hospital during the same period were selected as the control group;patients were collected The semen was tested by UU, and the As Ab levels of the two groups were detected by enzyme-linked immunosorbent assay(ELISA), and the semen parameters of the two groups were compared, and the semen parameters between the observation group and As Ab-negative patients and the control group were further divided. Results The positive rate of As Ab, the positive rate of UU, and the T-Ig of the observation group were significantly higher than those of the control group, and the difference was statistically significant(P<0.01);the UU infection rate of As Ab positive persons in the observation group was significantly higher than that of As Ab negative persons in the same group, The difference was statistically significant(P<0.01);the sperm density, sperm motility, a-grade sperm, and(a+b)-grade sperm of the observation group were significantly lower than those of the control group, and the rate of sperm deformity was significantly higher than that of the control group. There was statistical significance(P<0.01);the semen parameters of As Ab-positive patients in the observation group were significantly lower than those in the As Ab-negative group and the control group, and the differences were statistically significant(P<0.05);As Ab-positive patients in the observation group were infected with UU The semen parameters of the patients were significantly worse than those of the observation group with As Ab positive and no UU infection and the control group, and the differences were statistically significant(P<0.01). Conclusion The positive r

关 键 词：前列腺炎 抗精子抗体 精液分析 解脲支原体 

分 类 号：R697.33[医药卫生—泌尿科学] R698.2[医药卫生—外科学]