新型冠状病毒肺炎合并高血压靶点基因分析以及治疗中药预测  

Target genes analysis based on coronavirus disease 2019 with hypertension and exploration of traditional Chinese medicine

作　　者：张永健 李晓[2] 陈纪烨 王永成 周国锋 林芮 马度芳 杨金龙[2] 董峰 彭波[2] 林海青[2] ZHANG Yong-jian;LI Xiao;CHEN Ji-ye;WANG Yong-cheng;ZHOU Guo-feng;LIN Rui;MA Du-fang;YANG Jin-long;DONG Feng;PENG Bo;LIN Hai-qing(Shandong University of Traditional Chinese Medicine,Shandong Jinan 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Jinan 250011,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250011

出　　处：《中国医院药学杂志》2020年第13期1403-1409,1416,共8页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:81673970,81804036)。

摘　　要：目的:筛选并分析新型冠状病毒肺炎合并高血压靶点基因同时探索潜在治疗中药。方法:筛选出新型冠状病毒肺炎合并高血压共同靶点基因并进行蛋白互作,分析出高度值和血管紧张素转换酶2(ACE2)相关的两个模块的重要靶点基因。根据两个模块的重点靶点基因预测相关中医症状以及中药;根据两个模块的重要靶点基因进行GO功能分析和KEGG通路分析。结果:获得新型冠状病毒肺炎合并高血压共同靶点基因197个,获得高度值靶点基因18个和ACE2及其相关靶点基因共14个两个重要靶点基因模块,获得发热、头痛等中医症状和钩藤、麻黄、苦杏仁、青蒿、葛根等中药。两个模块的GO功能分析的细胞组分的前5个过程中的4个过程具有明显的一致性,KEGG通路分析有共同的8个信号通路。结论:获得了新型冠状病毒肺炎合并高血压靶点基因,并筛选和分析出重要靶点基因,同时也预测了具有潜在治疗作用的中药,为临床用药提供了参考。OBJECTIVE To screen and analyze the target genes of coronavirus disease 2019 with hypertension and explore potential therapeutic traditional Chinese medicine.METHODS The common target genes of coronavirus disease 2019 with hypertension were screened out and protein interactions were performed. The important target genes of two modules related to high value and angiotensin-converting enzyme 2(ACE2) were analyzed. Relevant TCM symptoms as well as TCM were predicted based on the key target genes of the two modules;GO functional analysis and KEGG pathway analysis were performed based on the important target genes of the two modules.RESULTS 197 common target genes of coronavirus disease 2019 with hypertension were obtained, 18 high value target genes and 14 important target gene modules of ACE2 and its related target genes were obtained, and TCM symptoms such as fever and headache and traditional Chinese medicines such as Uncaria rhynchophylla, Ephedra sinica, Bitter almond, Artemisia annua, and Kudzuvine root were obtained. The four processes in the first five processes of the cellular component of the GO functional analysis of the two modules have significant consistency, and the KEGG pathway analysis has eight signaling pathways in common.CONCLUSION The target genes of coronavirus disease 2019 complicated with hypertension were obtained, and the important target genes were screened and analyzed. At the same time, the traditional Chinese medicines with potential therapeutic effects were also predicted, which provided a reference for clinical medication.

关 键 词：新型冠状病毒肺炎 高血压 靶点基因 蛋白相互作用 信号通路 

分 类 号：R96[医药卫生—药理学]