血清25-羟维生素D水平与冠心病的相关性  

Correlation between serum 25-hydroxyvitamin D level and coronary heart disease

作　　者：韦美玉 滕震 吕荣荣 杨建国[1] Wei Meiyu;Teng Zhen;Lv Rongrong(Department of Internal Medicine-Cardiovascular,Cangzhou Central Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市中心医院心血管内科,061000

出　　处：《中华保健医学杂志》2020年第4期380-383,共4页Chinese Journal of Health Care and Medicine

基　　金：沧州市科技计划项目(172302123)。

摘　　要：目的分析血清25-羟维生素D水平(25-OH-VD)与冠心病的相关性。方法回顾性选取沧州市中心医院2017年3月~2018年12月收治的疑似为冠心病312例患者,年龄范围为42~80岁,将无冠心病的98例做为对照组,确诊为冠心病的214例患者为观察组,其中稳定性心绞痛(S组)72例,急性冠状动脉综合征(A组)124例。征得患者同意后行冠状动脉造影检查,按冠状动脉病变支数分为单支病变组65例和多支病变组77例。对比分析其收缩压(SPB)、舒张压(DPB)、25-OH-VD、高敏反应蛋白(hs-CRP)、总胆固醇(TC)、三酰甘油(TG)、葡萄糖(GLU)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标。结果观察组hs-CRP、TC、TG和LDL-C水平明显高于对照组,25-OH-VD、HDL-C、SPB和DPB均明显高于对照组,差异有统计学意义(P<0.05)。A组25-OH-VD水平明显低于S组,hs-CRP和TG水平明显高于S组,差异均有统计学意义(P<0.05);多支病变组25-OH-VD水平明显低于单支病变组,hs-CRP水平明显高于单支病变组,差异有统计学意义(P<0.05)。血清25-OH-VD随冠状动脉狭窄严重程度增加而显著降低,差异有统计学意义(P<0.05)。结论早期对冠心病患者进行血清25-OH-VD筛查,根据实际情况适当补充维生素D,为冠心病的早期预测提供有效参考。Objective To analyze of the correlation between serum 25-hydroxyvitamin D level and coronary heart disease.Methods A total of 312 patients with suspected coronary heart disease treated in our hospital from March 2017 to December 2018 were selected as the research subjects.According to the"Nomenclature and Diagnosis Standards of Ischemic Heart Disease"formulated by WHO,98 patients with non-coronary heart disease were used as the control group and 214 patients with coronary heart disease were used as the study group.The study group was divided into 72 cases of stable angina pectoris(group S)and 124 cases of acute coronary syndrome(group A)according to the type of coronary heart disease.Group A was further divided into 65 cases of simple vessel group and 77 cases of multi-vessel group according to the number of coronary lesions.SPB,DPB,25-OH-VD,hs-CRP,TC,HDL-C,LDL-C and TG were compared and analyzed.Result The level of hs-CRP,TC,TG,LDL-C,SPB and DPB levels in the study group were significantly higher than those in the control group.The level of 25-OH-VD and HDL-C in the study group were significantly lower than those in the control group(P<0.05).The level of 25-OH-VD in group A were significantly lower than those in group S.The level of hs-CRP and TG in group A were significantly higher than those in group S(P<0.05).The level of 25-OH-VD in the multi-vessel disease group was significantly lower than that in the single-vessel disease group(P<0.05).The level of hs-CRP in the multi-vessel disease group was significantly higher than that in the single-vessel disease group(P<0.05).The level of 25-OH-VD is inversely related to coronary stenosis in patients with coronary heart disease.The level of 25-OH-VD was decreased significantly with increasing severity of coronary stenosis(P<0.05).Conclusion Early screening of coronary heart disease patients with serum 25-OH-VD,and appropriating supplementation of vitamin D according to the actual situation can provide an effective reference for the early prediction of coronary heart

关 键 词：血清25-羟维生素D 冠心病 急性冠状动脉综合征 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]