Changes in sensorimotor regions of the cerebral cortex in congenital amusia:a case-control study  

作　　者：Jun-Jie Sun Xue-Qun Pan Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu 

机构地区：[1]Department of Radiology,the Second Xiangya Hospital of Central South University,Changsha,Hunan Province,China [2]Department of Radiology,the Affiliated Zhuzhou Hospital of Xiangya College of Medicine,Central South University,Zhuzhou,Hunan Province,China [3]Lister Hill National Center for Biomedical Communication,National Library of Medicine,Bethesda,MD,USA [4]Medical Psychological Center,the Second Xiangya Hospital of Central South University,Changsha,Hunan Province,China

出　　处：《Neural Regeneration Research》2021年第3期531-536,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81771172(to DXW),81671671(to JL);the Second Xiangya Hospital Start-Up Fund,China。

摘　　要：Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019.

关 键 词：congenital amusia degree centrality lifelong impairment local functional connectivity music discrimination primary motor area primary sensorimotor area primary sensory area resting-state functional magnetic resonance imaging voxel-based analysis 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学]