吡非尼酮联合糖皮质激素对特发性肺间质纤维化患者肺功能的影响  

Effects of Pifenidone Combined with Glucocorticoid on Pulmonary Function in Patients with Idiopathic Pulmonary Interstitial Fibrosis

作　　者：邹永祎 尹正海[1] Zou Yongyi;Yin Zhenghai(Department of Respiratory,Nanyang No.2 People's Hospital,Nanyang 473000)

机构地区：[1]南阳市第二人民医院呼吸一病区,南阳473000

出　　处：《数理医药学杂志》2020年第9期1401-1402,共2页Journal of Mathematical Medicine

摘　　要：目的:研究吡非尼酮联合糖皮质激素对特发性肺间质纤维化患者肺功能的影响。方法:选择2017年4月~2018年7月某院收治的82例特发性肺间质纤维化患者,根据随机双盲法分为对照组和观察组各41例。对照组应用糖皮质激素治疗,观察组在对照组基础上应用吡非尼酮治疗,观察治疗后两组临床疗效及治疗前、3个月后肺功能指标。结果:观察组的总有效率(95.12%)明显高于对照组(80.49%),FVC、FEV1水平较对照组高,差异具有统计学意义(P<0.05)。结论:应用吡非尼酮联合糖皮质激素明显改善特发性肺间质纤维化患者肺功能,且临床疗效较好,值得应用推广。Objective:To study the effects of pifenidone combined with glucocorticoid on pulmonary function in patients with idiopathic pulmonary interstitial fibrosis.Methods:82 patients with idiopathic pulmonary interstitial fibrosis treated in a hospital from April 2017 to July 2018 were selected and divided into two groups according to random double-blind method,with 41 cases in each group.The control group was treated with glucocorticoid,while the observation group was treated with pifenidone on the basis of the control group.The clinical efficacy,adverse reactions and pulmonary function indexes before and after treatment in the two groups were observed.Results:The total effective rate of the observation group(95.12%)was significantly higher than that of the control group(80.49%).The levels of FVC and FEV1 were higher than those of the control group,and the incidence of adverse reactions was lower than that of the control group,with statistically significant difference(P<0.05).Conclusion:Pifenidone combined with glucocorticoid can significantly improve pulmonary function,reduce the incidence of adverse reactions and improve the curative effect in patients with IPF,which is worthy of application and promotion.

关 键 词：特发性肺间质纤维化 吡非尼酮 糖皮质激素 

分 类 号：R563.9[医药卫生—呼吸系统]