宫腔灌注重组人粒细胞刺激因子治疗薄型子宫内膜的疗效  

Effect of Intrauterine Perfusion With Recombinant Human Granulocyte Stimulating Factor on Thin Endometrium

作　　者：李彩娟[1] 何瑞玲 LI Caijuan;HE Ruiling(Jiangmen Women and Children Health Care Center for Reproductive Medicine,Jiangmen Guangdong 529000,China)

机构地区：[1]江门市妇幼保健院生殖医学中心,广东江门529000

出　　处：《中国卫生标准管理》2020年第16期36-38,共3页China Health Standard Management

摘　　要：目的探讨宫腔内灌注重组人粒细胞集落刺激因子治疗薄型子宫内膜的疗效及安全性。方法选取2018年1月1日—2019年4月31日本院生殖医学中心就诊的薄型子宫内膜不孕患者58例,按照治疗方法的不同,分为对照组与研究组,其中30例接受G-CSF宫腔灌注治疗为研究组,另外28例接受芬吗通(雌二醇片/雌二醇地屈孕酮片)治疗设为对照组,对比两组患者疗效。结果治疗前,两组患者的Em、RI、A型子宫内膜率差异无统计学意义(P>0.05);治疗后,研究组的Em均高于对照组,RI值、A型子宫内膜率低于对照组,有统计学意义(P<0.05)。结论宫腔灌注重组人粒细胞刺激因子治疗薄型子宫内膜临床疗效显著,值得在临床进一步研究,探讨其质量剂量、时机和灌注次数,对不孕不育的治疗有重要意义。Objective To investigate the efficacy and safety of intrauterine infusion of recombinant human granulocyte colony stimulating factor in the treatment of thin endometrium.Methods From January 1,2018 to April 31,2019,58 patients with thin endometrial infertility were selected and divided into control group and study group according to different treatment methods.Among them,30 patients received G-CSF intrauterine infusion therapy as the study group,and the other 28 patients received Femoston therapy as the control group.Results Before treatment,there was no significant difference in Em,RI and type A endometrial rate between the two groups(P>0.05).After treatment,the Em of the study group was higher than that of the control group,while the RI value and type A endometrial rate were lower than those of the control group(P<0.05).Conclusion Intrauterine infusion of recombinant human granulocyte stimulating factor is effective in the treatment of thin endometrium,which is worthy of further clinical study.It is of great significance to discuss its mass dose,timing and perfusion times for the treatment of infertility.

关 键 词：宫腔灌注 重组人粒细胞刺激因子 芬吗通片 薄型子宫内膜 子宫内膜厚度 临床疗效 

分 类 号：R711[医药卫生—妇产科学]