超冷器官保存技术及应用  

Supercooling organ preservation technology and its application

作　　者：卢强[1,2,3] 张炜 杨丽斐[2,3] 吕毅 Lu Qiang;Zhang Wei;Yang Lifei;Lyu Yi(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院肝胆外科,710061 [2]精准外科与再生医学国家地方联合工程研究中心 [3]陕西省再生医学与外科工程研究中心

出　　处：《器官移植》2020年第5期543-546,共4页Organ Transplantation

基　　金：教育部创新团队发展计划(IRT_16R57)。

摘　　要：在器官移植手术中,器官保存的主要目的是保持离体器官内部组织细胞的活性,为器官转运及分配、受者术前评估以及手术团队准备赢得时间。器官保存的主要方法可分为常温机械灌注保存和低温保存。其中低温保存是目前临床上最为常用的器官保存方法,但在低温保存状态下,组织细胞内部仍存在代谢活动,这导致器官的长时间保存极为困难。超冷器官保存技术是一种新型的低温器官保存技术,极大地延长了器官的保存时间,未来有望成为器官保存的重要手段,为“器官库”的建立提供技术支持。The main purpose of organ preservation in organ transplantation is to maintain tissue and cell activity of donor organs so as to gain time for allocation and transportation of the organ,preparation of the recipient and organization of staff and facilities.The main principles of organ preservation can be divided into normothermic mechanical perfusion and cryopreservation.Cryopreservation is the favourite organ preservation method in clinical practice currently.However,the metabolic activity still exists in donor organs preserved with current cryopreservation technique,which makes the long-term preservation of organs extremely difficult.The supercooling organ preservation is a new type of cryopreservation technology,which greatly prolongs the preservation time of organs.It is expected to become an important organ preservation technique in the future,and it will provide technical support for the establishment of"organ bank".

关 键 词：器官移植 器官保存 超冷器官保存 静态冷保存 细胞代谢 常温机械灌注 亚低温机械灌注 低温机械灌注 

分 类 号：R617[医药卫生—外科学]