镰刀菌所致皮肤感染的文献回顾  

Skin fusariosis:a literature review

作　　者：杨亚敏 李东明[1] YANG Ya-Min;LI Dong-Ming(Department of Dermatology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院皮肤科真菌实验室,北京100191

出　　处：《菌物学报》2020年第8期1451-1475,共25页Mycosystema

基　　金：国家自然科学基金(C31770013,H81571967)。

摘　　要：镰刀菌主要为植物致病菌,但也可引起严重人类感染。镰刀菌病临床表现形式多样,本文主要综述相关的皮肤感染,分为局限性皮肤感染及播散性感染,诊断多较困难。由于该属真菌对抗真菌药物存在天然耐药,播散性镰刀菌病死亡率可达80%–90%。本文对Medline和中文文献数据库中的相关文献进行了系统查阅和分析,综合归纳了镰刀菌所致皮肤感染的致病种、地域分布、危险因子、临床表现形式、药物敏感性及其诊疗方案等,该综述对全面了解镰刀菌病的特征及对临床医师对本病的诊断具有重要的意义。Fusarium spp.are plant pathogens,but can cause serious human infections.The clinical manifestations of fusarium disease are diverse,including skin infection and disseminated infection,and the diagnosis is often challengable.This article mainly reviews the manifestations of skin infection.Because natural drug resistance is commonly found in Fusarium species,disseminated fusariosis has a mortality rate of 80%–90%.A comprehensive understanding of the characteristics of fusarium is of great significance to clinicians.For setting the research strategy,this paper systematically reviews and analyzes related literature in Medline and Chinese Literature Database and comprehensively summarizes the pathogenic species,regional distribution,risk factors,pathological characteristics,clinical manifestations,drug sensitivity,diagnosis and treatment of fusariosis.This review is expected to be helpful to comprehensive understanding of the characteristics of fusariosis and disease diagnosis by clinicians.

关 键 词：镰刀菌 镰刀菌病 真菌感染 皮下组织感染 皮肤结构感染 药物敏感性 

分 类 号：R756[医药卫生—皮肤病学与性病学]