恶性疟原虫抗药性基因研究现状  

Research status of drug resistance genes of Plasmodium falciparum

作　　者：张咏梅[1] ZHANG Yong-mei(Institute of Pathogenic Biology,Tianjin Centers for Disease Control and Prevention,Tianjin,300011,China)

机构地区：[1]天津市疾病预防控制中心病原生物检测所,天津300011

出　　处：《职业与健康》2020年第14期2001-2003,2007,共4页Occupation and Health

摘　　要：目前恶性疟原虫几乎对所有抗疟药物都产生了抗药性,研究与恶性疟原虫抗药性相关的恶性疟原虫氯喹抗药转运蛋白基因(Pfcrt)和恶性疟原虫多药抗药性基因(Pfmdr1)以及恶性疟原虫Kelch螺旋体蛋白基因(K13)突变有助于建立快速有效的疟原虫抗药性分子监测技术,对实现全球消除疟疾目标有着重要的意义。本文对恶性疟原虫药物抗性基因研究现状进行了综述。At present,Plasmodium falciparum is resistant to almost all antimalarial drugs.The study on mutations of Plasmodium falciparum chloroquine resistant transporter gene(Pfcrt),Plasmodium falciparum multidrug resistance genes(Pfmdr1)and Plasmodium falciparum Kelch spirochete protein gene(K13)contributes to the establishment of a rapid and effective molecular monitoring technology for malaria resistance,which is of great significance to the global goal of eliminating malaria.In this paper,the current status of the study on drug resistance genes of Plasmodium falciparum is reviewed.

关 键 词：恶性疟原虫 抗药性 恶性疟原虫氯喹抗药转运蛋白基因 恶性疟原虫多药抗药性基因 恶性疟原虫Kelch螺旋体蛋白基因 

分 类 号：R382.31[医药卫生—医学寄生虫学]