Severer nodular lesion in white matter than in gray matter in simian immunodeficiency virus-infected monkey, but not closely correlated with viral infection  

作　　者：Jingdong Zhang Howard Fox Huangui Xiong 

机构地区：[1]Department ofAnesthesiology,University of Cincinnati College of Medicine,Cincinnati,OH 45267,USA [2]Department of Pharmacology and Experiment Neuroscience,University of Nebraska Medical Center,Omaha,NE 68198,USA.

出　　处：《The Journal of Biomedical Research》2020年第4期292-300,共9页生物医学研究杂志（英文版）

基　　金：supported by R01 NS063878,R01 NS077873 and P30 MH062261(to H.X.and H.S.F.)。

摘　　要：Immune cell accumulation and white matter anomaly are common features of HIV(human immunodeficiency virus)-infected patients in combination antiretroviral therapy(cART) era.Neuroimaging tests on cART treated patients displayed prominent diffuse white matter lesions.Notably,immune cell nodular lesion(NL) was a conspicuous type of pathological change in HIV/SIV(simian immunodeficiency virus) infected brain before cART.Therefore,we used SIV infected brain to investigate the distribution of those NLs in gray and white matters.We found a significant higher number of NLs in white matter than that in gray matter.However,virus infection correlated with macrophage NLs but not with microglia NLs,especially in white matter.In addition,NLs interrupted white matter integrity more severely,since even tiny nodules could disconnect nerve fibers in white matter tracts.In the gray matter with dense myelinated axons,NLs obviously encroached those fibers;in the area of few myelinated axons,small nodules well co-localized with extracellular matrix between neurons.

关 键 词：simian immunodeficiency virus-infected monkey white matter tract nodular lesions microglia nodules perivascular cuffing nerve fiber disconnection 

分 类 号：R512.91[医药卫生—内科学]