19F磁共振成像造影剂研究进展  

Research Progress on 19FMagnetic Resonance Imaging Tracer

作　　者：孟凡强 刘燕 吴勇杰 陶可[1] 孙康[1] MENG Fanqiang;LIU Yan;WU Yongjie;TAO Ke;SUN Kang(State Key Lab of Metal Matrix Composites,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,P.R.China)

机构地区：[1]上海交通大学材料科学与工程学院金属基复合材料国家重点实验室,上海200240

出　　处：《影像科学与光化学》2020年第5期753-762,共10页Imaging Science and Photochemistry

基　　金：国家自然科学基金项目(31671027,31671004)资助。

摘　　要：19F磁共振成像(19Fmagnetic relaxation imaging,19FMRI)技术因其无内源性背景噪声而被广泛应用于生物医学研究领域。磁共振成像技术被提出后,19FMRI造影剂的研究主要集中于全氟化碳类有机物,这类有机物具有高的19F载量、合适的弛豫时间、高的影像信噪比,同时可以通过修饰功能性的基团实现多模式造影。近年来,19FMRI造影剂由全氟化碳等有机物逐渐向无机物延伸,出现了无机氟化物纳米粒子造影剂。本文主要介绍了19FMRI造影剂的种类、研究现状和应用前景。Because of no background noise in vivo,19Fmagnetic relaxation imaging(19FMRI)has been widely used in biomedical research.Perfluorocarbons molecules are the main kinds of 19FMRI imaging tracers.The organic fluoride can achieve high 19Fdensity,suitable relaxation time,high signal to noise ratio,as well as multimodal imaging by modification with functional groups.In recent years,19FMRI imaging tracers have been gradually developed from organic compounds to inorganic compounds.In this review,we summarized the types,research status and application prospects of 19FMRI imaging tracers.

关 键 词：19F磁共振成像 MRI造影剂 全氟化碳 氟化钙 

分 类 号：R445.2[医药卫生—影像医学与核医学]