钆掺杂碳量子点的制备及其双模态成像研究进展  

Progress in Research on the Preparation of Gadolinium-doped Carbon Dots and Their Bimodal Imaging

作　　者：马逸骅 陈琳[2] 杨永珍[2] 于世平[3] 苏秀琴[3] MA Yihua;CHEN Lin;YANG Yongzhen;YU Shiping;SU Xiuqin(Imaging Department,Shanxi Medical University,Taiyuan 030001,Shanxi,P.R.China;Key Laboratory of Interface Science and Engineering in Advanced Materials,Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,Shanxi,P.R.China;Department of Interventional Therapy,Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,P.R.China)

机构地区：[1]山西医科大学医学影像学系,山西太原030001 [2]太原理工大学新材料界面科学与工程教育部重点实验室,山西太原030024 [3]山西医科大学第二医院介入治疗科,山西太原030001

出　　处：《影像科学与光化学》2020年第5期763-770,共8页Imaging Science and Photochemistry

基　　金：山西省优秀人才科技创新项目(201805D211001);国家自然科学基金青年基金项目(51803148)资助。

摘　　要：荧光-磁共振成像(MRI)双模态分子探针突破了单一分子影像探针在灵敏度以及软组织分辨率等方面的局限性,在诊断和治疗等医学领域具有良好的应用潜力。钆掺杂碳量子点(Gd-CDs)是一种典型的荧光-MRI双模态分子探针,因其优异的荧光性能、良好的核磁共振成像能力和生物相容性等优点,在肿瘤的靶向性成像和监控诊疗方面具有广泛的应用前景。本文综述了目前Gd-CDs的制备、性能及其在双模态成像应用的研究现状,并提出目前存在的问题和前景展望。Fluorescence-magnetic resonance imaging(MRI)dual-modal molecular probes,which breaks through the limitation of single molecular imaging probes in terms of sensitivity and soft tissue resolution,has attracted tremendous attention in the fields of diagnosis and treatment.Gadolinium-doped carbon dots(Gd-CDs)is a typical fluorescence-MRI dual-modal molecular probe.With excellent optical properties,good MRI capability and low toxicity,Gd-CDs has a wide application prospect in tumor targeting imaging and treatment monitoring.This work summarizes the research status of the preparations,performance,and applications of Gd-CDs in bimodal imaging.Present problems and prospects are also put forward.

关 键 词：荧光成像 磁共振成像 双模态分子探针 钆掺杂碳量子点 

分 类 号：R445.2[医药卫生—影像医学与核医学] TB383.1[医药卫生—诊断学]