自然杀伤(NK)细胞治疗新型冠状病毒感染肺炎方案的探讨和展望  

Discussion and prospect of infusion of NK cells in the treatment of SARS-CoV-2 infection

作　　者：范晓乐 王水平 吴炳义[1] 蔡程程 张军一[1] 李妍妍 孟玉茹 FAN Xiaole;WANG Shuiping;WU Bingyi;CAI Chengcheng;ZHANG Junyi;LI Yanyan;MENG Yuru(Precision Medicine Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515;Chinese People’s Liberation Army No.964 Hospital,Changchun 130062;School of Public Health,Southern Medical University,Guangzhou 510515;Department of Cardiology,Air Force General Hospital,PLA,Beijing 100142,China)

机构地区：[1]南方医科大学南方医院精准医学中心,广东广州510515 [2]解放军第964医院放疗科,吉林长春130062 [3]南方医科大学公共卫生学院,广东广州510515 [4]空军特色医学中心心内科,北京100142

出　　处：《细胞与分子免疫学杂志》2020年第5期457-461,共5页Chinese Journal of Cellular and Molecular Immunology

摘　　要：探讨自然杀伤(NK)细胞治疗严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新冠病毒感染肺炎(COVID-19)的可行性和潜力。通过回顾性分析已有NK细胞的抗病毒研究和应用成果,并依据该细胞的特点和性质,设计NK细胞治疗SARS-CoV-2感染肺炎的研究方案。NK细胞作为免疫系统的重要组成部分,抗病毒生理特点明确,也起着免疫防御、免疫监视和免疫调节功能,临床应用已证明具有安全性和有效性。现在,SARS-CoV-2传染性强、危害大,易造成不可逆性的肺损伤,虽然通过隔离能有效防控,但鉴于尚无特效的治疗药物,为了未雨绸缪,避免可能造成的更大损失,研究一套有效的治疗方案仍非常必要。This article aims at investigating the feasibility and potential of natural killer(NK)cells to treat corona virus disease 2019(COVID-19)caused by severe acute respiratory syndrome corona virus 2(SARS-CoV-2).Through retrospective analysis of existing anti-virus researches and clinical application results of NK cells,and based on the characteristics and properties of this cell,we designed a plan for NK cells to treat COVID-19.As an important part of the immune system,NK cells have clear anti-viral ability.In addition,it also plays the role in immune defense,immune surveillance and immune regulation.Many clinical applications have proved the safety and effectiveness of NK cell application.Currently COVID-19 is highly contagious and harmful to people,and easy to cause irreversible lung damage.Although quarantine can effectively prevent and control viral infections,there is no effective drug treatment available.To avoid further greater losses,it is tremendously necessary to investigate an effective treatment plan.

关 键 词：自然杀伤(NK)细胞 严重急性呼吸综合征冠状病毒2(SARS-CoV-2) 新型冠状病毒 治疗 综述 

分 类 号：R392.12[医药卫生—免疫学] R563.1[医药卫生—基础医学]