醒脑静注射液联合脑苷肌肽注射液治疗急性脑卒中的临床研究  

Clinical Research on Xingnaojing Injection Combined with Cattle Encephalon Glycoside and Ignotin Injection in the Treatment of Acute Stroke

作　　者：李红涛 李东风[1] 李雅琳[1] LI Hongtao;LI Dongfeng;LI Yalin(Dept.of ICU,Fuyang People’s Hospital,Anhui Fuyang 236800,China)

机构地区：[1]阜阳市人民医院重症医学科,安徽阜阳236800

出　　处：《中国医院用药评价与分析》2020年第6期667-669,674,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：安徽省科技计划项目(No.1604a0802150)。

摘　　要：目的:探讨醒脑静注射液联合脑苷肌肽注射液治疗急性脑卒中的临床疗效。方法:根据随机数字表法,将2016年3月至2019年7月阜阳市人民医院收治的急性脑卒中患者168例分为对照组和研究组,每组84例。对照组患者在常规治疗的基础上联合脑苷肌肽注射液治疗,研究组患者在对照组的基础上联合醒脑静注射液治疗。比较两组患者临床疗效、颅内动脉血流情况、相关血清指标水平变化的差异,记录两组患者治疗期间不良反应发生情况。结果:治疗2周后,研究组患者的总有效率为82.14%(69/84),明显高于对照组的66.67%(56/84),差异有统计学意义(P<0.05)。治疗2周后,两组患者生长分化因子15、神经胶质纤维酸性蛋白及磷脂酰丝氨酸水平与治疗前相比均明显降低,且研究组患者与对照组相比明显降低,差异均有统计学意义(P<0.05)。治疗后,两组患者基底动脉、椎动脉和大脑前、中及后动脉血流与治疗前相比均明显升高,且研究组患者与对照组相比明显升高,差异均有统计学意义(P<0.05)。治疗期间,研究组、对照组患者不良反应发生率分别为10.71%(9/84)、7.14%(6/84),差异无统计学意义(P>0.05)。结论:醒脑静注射液联合脑苷肌肽注射液治疗急性脑卒中的疗效显著,可有效改善患者颅内动脉血流状况,改善血清生长分化因子15、神经胶质纤维酸性蛋白及磷脂酰丝氨酸水平,且用药安全性较好。OBJECTIVE:To probe into the clinical efficacy of Xingnaojing injection combined with cattle encephalon glycoside and ignotin injection in the treatment of acute stroke.METHODS:168 patients with acute stroke admitted into Fuyang People’s Hospital from Mar.2016 to Jul.2019 were selected and divided into control group and research group via random number table,with 84 cases in each group.The control group was treated with cattle encephalon glycoside and ignotin injection based on conventional therapy,while the research group was given Xingnanjing injection based on the control group.Differences in clinical efficacy,intracranial arterial blood flow,changes of related serum indicators were compared between two groups,incidences of adverse drug reactions of the two groups were recorded during treatment.RESULTS:After 2-week treatment,the total effective rate of research group was 82.14%(69/84),which was significantly higher than that of the control group(66.67%,56/84),with statistically significant difference(P<0.05).After 2-week treatment,the growth differentiation factors-15(GDF-15),glial fibrillary acidic protein(GFAP)and phosphatidylserine(Ps)levels of both groups had been significantly decreased,and those of the research group were significantly lower than the control group,with statistically significant difference(P<0.05).After treatment,the blood flow in basilar artery,vertebral artery,anterior cerebral artery,middle cerebral artery and posterior cerebral artery of both groups had been significantly increased,and those of the research group were significantly higher than the control group,with statistically significant differences(P<0.05).During treatment,the incidences of adverse drug reactions of research group and control group were respectively 10.71%(9/84)and 7.14%(6/84),the difference had no statistical significance(P>0.05).CONCLUSIONS:The efficacy of Xingnaojing injection combined with cattle encephalon glycoside and ignotin injection in the treatment of acute stroke is remarkable,which can effectively i

关 键 词：醒脑静注射液 脑苷肌肽 急性脑卒中 疗效 不良反应 

分 类 号：R932[医药卫生—生药学]