盐酸戊乙奎醚与间苯三酚治疗原发性痛经的临床疗效比较  

Comparison of Clinical Efficacy of Penehyclidine Hydrochloride and Phloroglucinol in the Treatment of Primary Dysmenorrhea

作　　者：殷溶[1] 韦凤 YIN Rong;WEI Feng(Dept.of Obstetrics and Gynecology,Chongqing Emergency Medical Center,Chongqing 400014,China)

机构地区：[1]重庆市急救医疗中心妇产科,重庆400014

出　　处：《中国医院用药评价与分析》2020年第6期695-697,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:比较盐酸戊乙奎醚与间苯三酚治疗原发性痛经的临床疗效。方法:选取2016年1月至2018年12月重庆市急救医疗中心收治的原发性痛经患者120例,按随机数字表法分为观察组和对照组,每组60例。观察组患者给予盐酸戊乙奎醚1 mg肌内注射,对照组患者给予间苯三酚80 mg肌内注射。观察两组患者用药前后的视觉模拟评分(visual analogue scale,VAS),药物起效时间、临床疗效及不良反应发生情况。结果:用药前,两组患者VAS评分的差异无统计学意义(P>0.05);观察组患者用药后15 min的VAS评分明显低于对照组,药物起效时间明显短于对照组,差异均有统计学意义(P<0.05);但两组患者用药后30、60 min的VAS评分比较,差异均无统计学意义(P>0.05)。两组患者的显效率、有效率及总有效率的差异均无统计学意义(P>0.05)。观察组患者的不良反应发生率为13.3%(8/60),明显高于对照组的1.7%(1/60),差异有统计学意义(P<0.05)。结论:盐酸戊乙奎醚与间苯三酚治疗原发性痛经安全有效,盐酸戊乙奎醚较间苯三酚起效更快,间苯三酚较盐酸戊乙奎醚不良反应更少。OBJECTIVE:To compare the clinical efficacy of penehyclidine hydrochloride and phloroglucinol in the treatment of primary dysmenorrhea.METHODS:Totally 120 patients with primary dysmenorrhea admitted into Chongqing Emergency Medical Center from Jan.2016 to Dec.2018 were extracted to be divided into the observation group and the control group via the random number table,with 60 cases in each group.The observation group was administrated with intramuscular injection of 1 mg penehyclidine hydrochloride,while the control group was given intramuscular injection of 80 mg phloroglucinol.Visual analogue scale(VAS)score,oneset time,clinical efficacy and adverse drug reactions of two groups were observed.RESULTS:Before treatment,the difference in VAS score between two groups was not statistically significant(P>0.05).After administration of 15 min,the VAS score of the observation group was significantly lower than that in the control group,the onset time of the observation group was significantly shorter than that in the control group,and the differences were statistically significant(P<0.05).After administration of 30 and 60 min,the difference in VAS score between two groups was not statistically significant(P>0.05).There was no statistically significant difference in significant efficiency,effective rate and total effective rate between two groups(P>0.05).The incidence of adverse drug reactions in the observation group was 13.3%(8/60),significantly higher than that in the control group 1.7%(1/60),and the difference was statistically significant(P<0.05).CONCLUSIONS:Penehyclidine hydrochloride and phloroglucinol are safe and effective in the treatment of primary dysmenorrhea.The onset time of penehyclidine hydrochloride is shorter than that of phloroglucinol,while the incidence of adverse drug reactions of phloroglucinol is lower than that of penehyclidine hydrochloride.

关 键 词：原发性痛经 盐酸戊乙奎醚 间苯三酚 

分 类 号：R971[医药卫生—药品]