慢性阻塞性肺疾病抗菌药物使用状况评价研究  

Evaluation of Application of Antibiotics in Chronic Obstructive Pulmonary Disease

作　　者：戴柔丽[1] 李歆 DAI Rouli;LI Xin(Dept.of Medical Administration,the Fourth Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210001,China;School of Pharmacy,Nanjing Medical University,Jiangsu Nanjing 211166,China;School of Medical Administration,Nanjing Medical University,Jiangsu Nanjing 211166,China)

机构地区：[1]南京医科大学第四附属医院医务部,江苏南京210001 [2]南京医科大学药学院临床药学系,江苏南京211166 [3]南京医科大学医政学院,江苏南京211166

出　　处：《中国医院用药评价与分析》2020年第6期709-711,715,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金(No.71673147)。

摘　　要：目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者抗菌药物使用情况及治疗情况。方法:选取2017—2019年在南京医科大学第四附属医院(以下简称“我院”)进行治疗的983例COPD患者的临床资料进行回顾性分析,统计分析抗菌药物使用种类、金额、药物利用指数(drug utilization index,DUI)及限定日费用(daily drug cost,DDC)等。结果:983例患者治疗过程中抗菌药物使用率为100%,其中使用1种抗菌药物的有735例,二联用药的有187例,三联用药的有52例,四联用药的有9例;每例患者平均使用抗菌药物(2.35±0.68)种;抗菌药物使用金额平均为(1573.9±17.52)元;第3代头孢菌素、氟喹诺酮类抗菌药物的使用率较高,分别为33.7%(331例)和25.7%(253例);DUI在1.0±0.1范围内的有左氧氟沙星、头孢噻肟、头孢哌酮舒巴坦和氟康唑;DDC排序居前5位的分别为替考拉宁、亚胺培南西司他丁、哌拉西林他唑巴坦、头孢西丁和头孢噻肟。结论:我院COPD治疗中抗菌药物的使用基本合理,但仍有可以改进的空间,需要进一步完善医院抗菌药物使用管理制度。OBJECTIVE:To investigate the application status and treatment process of antibiotics in chronic obstructive pulmonary disease(COPD).METHODS:Retrospective analysis was conduced on clinical data of 983 patients with COPD from the Fourth Affiliated Hospital of Nanjing Medical University(hereinafter referred to as“our hospital”)from 2017 to 2019.Categories,consumption sum,drug utilization index(DUI)and daily drug cost(DDC)were statistically analyzed.RESULTS:During the treatment,the application rate of antibiotics in 983 patients was 100%,among which 735 patients were given one kind of antibiotics,187 patients were given two kinds of antibiotics,52 patients were given three kinds of antibiotics and 9 patients were given four kinds of antibiotics.The average number of antibiotics used in each patient was 2.35±0.68.The average consumption sum of antibiotics used was(1573.9±17.52)yuan.The third generation cephalosporins and quinolones accounted for 33.7%(n=331)and 25.7%(n=253)of the total antibiotics used in our hospital.DUIs in the range of 1.0±0.1 were respectively levofloxacin,cefotaxime,cefoperazone sulbactam and fluconazole.The top five drugs ranked by DDC were respectively teicoplanin,imipenemcilastatin,piperacillintazobactam,cefoxitin and cefotaxime.CONCLUSIONS:The application of antibiotics in the treatment of COPD in our hospital is basically reasonable,but there is still room for improvement,and the management system of application of antibiotics in the hospital needs to be further improved.

关 键 词：抗菌药物 使用情况 慢性阻塞性肺疾病 

分 类 号：R978.1[医药卫生—药品]