经颅直流电刺激联合镜像神经元康复训练系统治疗颅脑损伤后青年抑郁患者的疗效  

Effects of transcranial direct current stimulation combined with mirror neuron rehabilitation training system on young patients with depression after traumatic brain injury

作　　者：李姣 冯海霞[1] 李亚斌[1] 王红霞 杨佳丽 马中睿 曹志刚 刘忠[1] LI Jiao;FENG Haixia;LI Yabin;WANG Hongxia;YANG Jiali;MA Zhongrui;CAO Zhigang;LIU Zhong(Rehabilitation Center Hospital of Gansu Province,Lanzhou 730000,China)

机构地区：[1]甘肃省康复中心医院,甘肃兰州730000

出　　处：《中国实用神经疾病杂志》2020年第17期1515-1519,共5页Chinese Journal of Practical Nervous Diseases

基　　金：兰州市人才创新创业项目(编号:2019-RC-40)。

摘　　要：目的观察经颅直流电刺激联合镜像神经元康复训练系统治疗颅脑损伤后青年抑郁患者的疗效。方法选取2019-02—2020-03于甘肃省康复中心医院神经康复科住院的颅脑损伤后青年抑郁患者51例,按照随机数表分为2组,观察组26例在常规康复训练的基础上接受经颅直流电刺激(tDCS)联合镜像神经元康复训练系统(MNST-V1.0)治疗,对照组25例在常规康复训练的基础上接受经颅直流电刺激(tDCS)治疗。分别于治疗前和治疗4周后采用汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)、贝克抑郁量表(BDI)、改良Barthel指数(MBI)对2组疗效进行评估。结果观察组和对照组治疗4周后HAMD、SDS、BDI及MBI评分均较治疗前明显改善,差异有统计学意义(P<0.05)。2组治疗前HAMD、SDS、BDI及MBI评分比较,差异无统计学意义(P>0.05),但治疗4周后观察组HAMD(11.4±5.3)分、SDS(42.1±6.5)分、BDI(10.7±3.9)分及MBI(75.15±12.91)分均较对照组明显改善,差异有统计学意义(P<0.05)。结论经颅直流电刺激联合镜像神经元康复训练系统对颅脑损伤后青年抑郁患者的疗效显著。Objective To observe the effect of transcranial direct current stimulation combined with mirror neuron rehabilitation training system on young depressed patients after brain injury.Methods According to the order of treatment by random number table method,patients with brain injury for rehabilitation at the Department of Neurologica Rehabilitation Medicine,Rehabilitation Center Hospital of Gansu Province from February 2019 to March 2020 were enrolled.On the basis of traditional rehabilitation training,patients were divided into observation group(tDCS+MNST,n=26)and control group(tDCS,n=25).4 weeks were a course of treatment.Both groups were assessed before treatment with the Hamilton depression scale(HAMD),the self-rating depression scale(SDS),the Beck depression inventory(BDI)and the modified Barthel index(MBI)and the again after 4 weeks treatment.Results After treatment,HAMD,SDS,BDI,MBI scores of both of two groups were improved significantly,the improvement was statistically significant(P<0.05).After 4 weeks treatment,observation group’s HAMD(11.4±5.3),SDS(42.1±6.5),BDI(10.7±3.9)and MBI(75.15±12.91)were significantly better than control group,the difference was statistically significant(P<0.05).Conclusion The effects of transcranial direct current stimulation combined with mirror neuron rehabilitation training system on young patients with depression after brain injury were significant.

关 键 词：颅脑损伤 经颅直流电刺激 镜像神经元康复训练系统 抑郁 日常生活能力 

分 类 号：R651.15[医药卫生—外科学]