甲巯咪唑和丙硫氧嘧啶治疗甲亢不良反应的临床对比  

A clinical study on the adverse effects of medetomidine and prothiorexamide in the treatment of hyperthyroidis

作　　者：郭峰 Guo Feng(Lianshan Hospital,Huludao,Liaoning,125000,China)

机构地区：[1]辽宁葫芦岛连山区医院,辽宁葫芦岛125000

出　　处：《当代医学》2020年第27期6-7,共2页Contemporary Medicine

摘　　要：目的探讨甲巯咪唑(MMI)和丙硫氧嘧啶(PTU)治疗甲亢不良反应的临床效果。方法选取2016年3月至2018年5月于本院接受治疗的90例甲亢患者,随机分为MMI组和PTU组,每组45例。MMI组患者使用甲巯咪唑进行治疗,PTU组患者使用丙硫氧嘧啶进行治疗,比较两组患者血细胞计数以及肝功能指标异常情况。结果治疗后,PTU组血小板计数、白细胞计数、红细胞计数总减少率(6.67%)明显低于MMI组(48.89%),差异有统计学意义(P<0.05);PTU组ALT、ALP、TBIL及DBIL的总异常率(37.78%)高于MMI组(2.22%),差异有统计学意义(P<0.05)。结论使用甲巯咪唑、丙硫氧嘧啶治疗甲亢患者均有一定效果,但甲巯咪唑易引起患者血细胞减少,丙硫氧嘧啶易损伤患者肝功能,临床使用时需严格按照治疗指征及患者具体情况选择用药。Objective To investigate the clinical effect of methimazole(MMI)and propylthiouracil(PTU)in the treatment of hyperthyroidism.Methods 90 patients with hyperthyroidism in our hospital from March 2016 to May 2018 were randomly divided into MMI group and PTU group,with 45 cases in each group.Patients in MMI group were treated with methimazole,and patients in PTU group were treated with propylthiouracil.The blood cell count and liver function indexes were compared between the two groups.Results After treatment,the total reduction rate of platelet count,white blood cell count and red blood cell count in PTU group(6.67%)was significantly lower than that in MMI group(48.89%),the difference was statistically significant(P<0.05).The total abnormal rate of ALT,ALP,TBIL and DBIL in PTU group(37.78%)was higher than that in MMI group(2.22%),the difference was statistically significant(P<0.05).Conclusion The use of methimazole and propylthiouracil in the treatment of hyperthyroidism patients have certain effect,but methimazole is easy to cause the reduction of blood cells,propylthiouracil is easy to damage the liver function of patients,so it is necessary to select drugs strictly according to the treatment indications and the specific conditions of patients in clinical use.

关 键 词：甲巯咪唑 丙硫氧嘧啶 甲亢 血细胞 肝功能 

分 类 号：R581.1[医药卫生—内分泌]