研究腹腔镜下卵巢打孔术(LOD)联合二甲双胍治疗难治性多囊卵巢综合征(PCOS)不孕的效果  

To study the effect of laparoscopic ovarian drilling(LOD)combined with metformin in the treatment of infertility with refractory polycystic ovary syndrome(PCOS)

作　　者：吴桂强 Wu Guiqiang(Department of Reproductive Surgery,Shenyang Oriental Jinghua Hospital,Shenyang,Liaoning,110003,China)

机构地区：[1]沈阳东方菁华医院生殖外科,辽宁沈阳110003

出　　处：《当代医学》2020年第27期79-81,共3页Contemporary Medicine

摘　　要：目的研究难治性多囊卵巢综合征(PCOS)不孕患者中应用腹腔镜下卵巢打孔术(LOD)联合二甲双胍治疗的临床效果。方法选取本院2018年7月至2019年2月收治的60例难治性多囊卵巢综合征(PCOS)不孕患者为研究对象,随机分为两组,每组30例。对照组患者给予二甲双胍治疗,实验组患者给予腹腔镜下卵巢打孔术(LOD)联合二甲双胍治疗。治疗后,两组均随访6个月。比较两组患者治疗后妊娠率、排卵率、FSH、雌二醇及睾酮、黄体生成素、生活质量评分。结果治疗后,实验组患者卵泡刺激素水平明显高于对照组,差异具有统计学意义(P<0.05)。实验组患者黄体生成素、雌二醇激素、睾酮水平均明显低于对照组,差异具有统计学意义(P<0.05);实验组患者生理职能、社会评分、精神健康、情感职能评分均高于对照组,差异具有统计学意义(P<0.05);实验组患者的排卵率为76.67%,明显高于对照组的60.00%,差异具有统计学意义(P<0.05);实验组患者妊娠率为63.33%,明显高于对照组的43.33%,差异具有统计学意义(P<0.05)。结论难治性多囊卵巢综合征不孕患者中应用腹腔镜下卵巢打孔术联合二甲双胍治疗效果理想,能够有效提高患者的妊娠率及排卵率,帮助患者尽快恢复健康,改善性激素水平,值得临床推广。Objective To study the clinical effect of laparoscopic ovarian drilling(LOD)combined with metformin in infertile patients with refractory polycystic ovary syndrome(PCOS).Methods 60 infertile patients with refractory polycystic ovary syndrome(PCOS)in our hospital from July 2018 to February 2019 were selected as the research subjects and randomly divided into two groups,with 30 cases in each group.The control group was given metformin treatment,the experimental group was given laparoscopic ovarian drilling(LOD)combined with metformin treatment.After treatment,both groups were followed up for 6 months.The pregnancy rate,ovulation rate,FSH,estradiol and testosterone,luteinizing hormone and quality of life scores were compared between the two groups.Results After treatment,the level of FSH in the experimental group was significantly higher than that in the control group(P<0.05).The levels of luteinizing hormone,estradiol hormone and testosterone in the experimental group were significantly lower than those in the control group(P<0.05).The scores of physiological function,social score,mental health and emotional function in the experimental group were higher than those in the control group(P<0.05).The ovulation rate in the experimental group was 76.67%,significantly higher than that in the control group(60.00%),the difference was statistically significant(P<0.05).The pregnancy rate of the experimental group was 63.33%,which was significantly higher than that of the control group(43.33%)(P<0.05).Conclusion Laparoscopic ovarian drilling combined with metformin in the treatment of infertility with refractory polycystic ovary syndrome has ideal effect,which can effectively improve the pregnancy rate and ovulation rate of patients,help patients recover health as soon as possible,and improve the level of sex hormone,which is worthy of clinical promotion.

关 键 词：腹腔镜下卵巢打孔术 二甲双胍 难治性多囊卵巢综合征 不孕 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]