Therapeutic efficacy of moxibustion plus medicine in the treatment of infertility due to polycystic ovary syndrome and its effect on serum immune inflammatory factors  

灸药结合治疗多囊卵巢综合征不孕的疗效及对血清免疫炎性因子水平的影响

作　　者：Ye Tie-jun Cheng Hong-xia 叶铁君;程红霞;张馥晴(翻译)(People's Hospital of Kaihua,Zhejiang 324300,China;不详)

机构地区：[1]People's Hospital of Kaihua,Zhejiang 324300,China

出　　处：《Journal of Acupuncture and Tuina Science》2020年第4期269-275,共7页针灸推拿医学（英文版）

摘　　要：Objective:To explore the effects and related mechanism of heat-sensitive moxibustion plus clomifene citrate capsules for infertility due to polycystic ovary syndrome(PCOS).Methods:A total of 70 patients were randomized into a control group and an observation group by the random number table method,with 35 cases in each group.The control group was treated with clomifene citrate capsules,while the observation group was treated with heat-sensitive moxibustion on the basis of the medications in the control group.The treatment course lasted for 6 menstrual cycles.The endometrial thickness and ovarian volume of the patients were measured before and after treatment.The levels of serum sex hormones,tumor necrosis factor-α(TNF-α)and nuclear factor-κB(NF-κB)were detected.Follow-up was performed for 1 year after treatment,and the pregnancy rate was recorded.Results:After treatment,the endometrium of the patients in both groups was significantly thickened,the ovarian volume was significantly reduced,and the intra-group differences were statistically significant(all P<0.05).The endometrium thickness and ovarian volume in the observation group were significantly different from those in the control group(both P<0.05).After treatment,the levels of serum testostrn(T)and luteinizing hormone(LH)in both groups decreased significantly,the level of estradiol(E2)increased obviously,and the intra-group differences were statistically significant(all P<0.05).The levels of serum T and LH in the observation group were lower than those in the control group,and the E2 level in the observation group was higher than that in the control group,and the between-group differences were statistically significant(all P<0.05).After treatment,the levels of serum TNF-αand NF-κB of the patients in both groups decreased,and the intra-group differences were statistically significant(all P<0.05).The levels of serum TNF-αand NF-κB in the observation group were significantly lower than those in the control group(both P<0.05).After 1-year follow-up,the p目的:探讨热敏灸加枸橼酸氯米芬胶囊治疗多囊卵巢综合征(PCOS)不孕及其相关作用机制.方法:将70例患者按随机数字表法分为对照组和观察组,每组35例.对照组予枸橼酸氯米芬胶囊治疗;观察组在对照组用药基础上加用热敏灸.治疗6个月经周期.治疗前后测定患者子宫内膜厚度和卵巢体积,并检测血清性激素、肿瘤坏死因子-α(TNF-α)和核转录因子-κB(NF-κB)水平.治疗结束后随访1年,记录受孕率.结果:治疗后,两组子宫内膜均明显增厚,卵巢体积均明显减小,与同组治疗前均有统计学差异(均P<0.05);观察组子宫内膜厚度、卵巢体积与对照组均有统计学差异(均P<0.05).治疗后,两组患者血清睾酮(T)和黄体生成素(LH)水平均显著降低,雌二醇(E2)水平明显升高,与同组治疗前均有统计学差异(均P<0.05);观察组血清T和LH水平低于对照组,E2水平高于对照组,组间差异均有统计学意义(均P<0.05).治疗后,两组患者的血清TNF-α和NF-κB水平均降低,与同组治疗前均有统计学差异(均P<0.05);观察组血清TNF-α和NF-κB水平均显著低于对照组(均P<0.05).随访1年,对照组受孕率为20.0%,观察组为51.5%,观察组受孕率高于对照组,差异有统计学意义(P<0.05).结论:热敏灸加枸橼酸氯米芬胶囊治疗PCOS不孕可增加患者子宫内膜厚度,减小卵巢体积,改善血清性激素紊乱状态,提高受孕率;这可能与其调整患者血清TNF-α和NF-κB等免疫炎性因子水平有关.

关 键 词：Moxibustion Therapy Heat-sensitive Moxibustion Polycystic Ovary Syndrome Gonadal Steroid Hormones Tumor Necrosis Factor-α NF-kappa B Infertility Female 

分 类 号：R246.3[医药卫生—针灸推拿学]