膝单间室骨性关节炎与骨质疏松症的关联分析  

Correlation analysis of compartment knee osteoarthritis and osteoporosis

作　　者：蔄元鹏 李桂石 王光达[2] 姜涛涛 王金伟 黄晨[1] Man Yuanpeng;Li Guishi;Wang Guangda;Jiang Taotao;Wang Jinwei;Huang Chen(Department of Orthopedics,Yantai Mountain Hospital,Yantai 264001,China;Department of Joint Orthopaedics,YantaiYuhuangding Hospital,Yantai 264000,China)

机构地区：[1]烟台市烟台山医院骨科,264001 [2]烟台毓璜顶医院骨关节外科,264000

出　　处：《国际生物医学工程杂志》2020年第3期226-230,243,共6页International Journal of Biomedical Engineering

基　　金：山东省自然科学基金(ZR2017LH022)。

摘　　要：目的研究膝单间室骨性关节炎(KOA)与骨质疏松症(OP)的关联性。方法选择年龄为50~80岁、体质量指数(BMI)为16.5~38的KOA患者118例为KOA组,其中排除继发性因素导致的合并OP患者。选择年龄与KOA组患者相匹配的未患KOA者42例。采集两组患者的年龄、BMI、骨密度(BMD)等数据。进行KOA和OP的关联分析,确定其关联程度,以揭示KOA发病、进展、预后与OP的关系。结果BMD与BMI具有相关性,BMD与年龄呈负相关,KOA和OP的发病率均与年龄存在相关性。KOA与OP存在较大关联性,且关联系数较大,KOA伴发OP的概率很高。对于KOA患者,其BMI较高时伴OP的可能性小,而BMI较低时伴发OP的可能性增加。结论OP为KOA的致病因素之一,临床中对KOA患者,在前术后都要进行抗OP治疗。Objective To study the relationship between compartmental kneeosteoarthritis(KOA)and osteoporosis(OP).Methods A total of 118 KOA patients with 50~80 years old and 16.5~38 of body mass index(BMI)were selected as the KOA group,in which the patient with OP caused by secondary factors were excluded.42 patients who did not suffer from KOA who matched the age of patients in the KOA group were selected.The age,BMI,bone mineral density(BMD)and other data of the two groups of patients were collected.The correlation analysis between KOA and OP was conducted to determine the degree of correlation,so as to reveal the relationship between the incidence,progression,prognosis of KOA and OP.Results BMD was correlated with BMI.BMD was negatively correlated with age.The incidence of KOA and OP was correlated with age.There is a large correlation between KOA and OP,and the probability of KOA associated with OP is high.For KOA patients,OP is less likely to be accompanied by a higher BMI,while OP is more likely to be accompanied by a lower BMI.Conclusions OP is one of the pathogenic factors of KOA.KOA patients should be treated with anti-OP before and after surgery.

关 键 词：膝单间室骨性关节炎 骨质疏松 环境致病因素 

分 类 号：R684.3[医药卫生—骨科学] R580[医药卫生—外科学]