β-七叶皂甙钠联合甘露醇对高血压性脑出血患者神经功能及颅内压的影响  

Effect of β-sodium Aescinate Combined with Mannitol on Nerve Function and Intracranial Pressure in Patients with Hypertensive Intracerebral Hemorrhage

作　　者：张档红 ZHANG Dang-hong(Lingbao Third People's Hospital Internal Medicine-Neurology,Lingbao Henan 472500,China)

机构地区：[1]灵宝市第三人民医院神经内科,河南灵宝472500

出　　处：《药品评价》2020年第12期58-60,共3页Drug Evaluation

摘　　要：目的:探讨β-七叶皂甙钠联合甘露醇治疗高血压性脑出血对患者神经功能、颅内压控制状况及炎症水平的影响。方法:选取2018年3月—2020年3月于我院就诊的86例高血压性脑出血患者,按随机数字表法分为两组,每组各43例。对照组予以甘露醇治疗,观察组加用β-七叶皂甙钠治疗。比较两组神经功能、颅内压、炎症水平及不良反应发生状况。结果:两组治疗前NIHSS评分、颅内压、IL-6及CRP相比,差异无统计学意义(P>0.05);观察组治疗后NIHSS评分、颅内压低于对照组,差异有统计学意义(P<0.05);观察组治疗后IL-6、CRP水平低于对照组,差异有统计学意义(P<0.05);两组均无严重不良反应。结论:β-七叶皂甙钠联合甘露醇可增强高血压性脑出血治疗效果,加快颅内压下降,抑制炎症反应蔓延,减轻神经功能损伤,安全可靠。Objective:To investigate the effect of β-sodium aescinate combined with mannitol on nerve function,intracranial pressure control and inflammatory levels in patients with hypertensive intracerebral hemorrhage.Methods:86 patients with hypertensive intracerebral hemorrhage who were treated in the hospital from March 2018 to March 2020 were divided into two groups according to random number table method,with 43 cases in each group.The control group was treated with mannitol,while the observation group was treated with β-sodium aescinate based on control group.The nerve function,intracranial pressure,inflammatory levels and adverse reactions were compared between the two groups.Results:There was no statistically significant difference in the NIHSS score,intracranial pressure,IL-6 and CRP between the two groups before treatment (P>0.05);The NIHSS score and intracranial pressure in the observation group were lower than those in the control group after treatment (P<0.05);The levels of IL-6 and CRP in the observation group were lower than those in the control group after treatment (P<0.05);There were no severe adverse reactions in the two groups.Conclusion:β-sodium aescinate combined with mannitol in treatment of hypertensive intracerebral hemorrhage can enhance curative effects,accelerate the decrease in the intracranial pressure,stop the spreading of inflammatory response,and alleviate nerve function injury,which is safe and reliable and worthy of extensive application.

关 键 词：高血压性脑出血 Β-七叶皂甙钠 甘露醇 神经功能 不良反应 

分 类 号：R651.15[医药卫生—外科学]