急性缺血性脑卒中患者血浆PMP和EMP水平与颈动脉狭窄的相关性研究  

Correlation between the levels of plasma PMP and EMP and carotid artery stenosis in patients with acute ischemic stroke

作　　者：付晓玲[1] 杜茜 王军 曲立新[1] FU Xiaoling;DU Qian;WANG Jun;QU Lixin(Dezhou People’s Hospital,Dezhou 253014,China;The First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital),Jinan 250021,Chian;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]德州市人民医院,德州253014 [2]山东第一医科大学第一附属医院(山东省千佛山医院),济南250021 [3]山东省中医药大学附属医院,济南250011

出　　处：《济宁医学院学报》2020年第4期260-262,共3页Journal of Jining Medical University

基　　金：山东省医药卫生科技发展项目(2017WS765)。

摘　　要：目的探讨急性缺血性脑卒中(AIS)患者血浆血小板微粒体(PMP)和内皮细胞微粒体(EMP)水平与颈动脉狭窄(CAS)的关系。方法以德州市人民医院神经内科2018年9月至2019年12月收治的AIS患者178例为研究对象。以狭窄率≥50%为脉狭窄组(93例)和狭窄率<50%为对照组(85例),分析PMP和EMP含量与CAS的相关性。结果狭窄组的血浆PMP和EMP水平显著高于对照组(P<0.05)。控制其他影响因素后,PMP和EMP水平是影响CAS患者的独立预测因子。结论血浆PMP和EMP水平可作为临床上评估CAS发生的指标。Objective To explore the relationship between circulating platelets microparticles(PMP)and endothelial microparticls(EMP)and carotid artery stenosis(CAS)in patients with acute ischemic stroke(AIS).Methods 178 Patients with AIS hospitalized from September,2018 to December,2019 in Dezhou People’s Hospital were selected.There were 93 patients in the stenosis group and 85 in the control group.The stenosis rate≥50%was used as the pulse stenosis group and the stenosis rate<50%was used as the control group.The correlation between PMP and EMP contents and CAS was analyzed.Results The level of plasma PMP and EMP in the stenosis group were significantly higher than those in the control group(P<0.05).After controlling for other influencing factors,PMP and EMP levels were found to be independent predictors affecting patients with CAS.Conclusion Circulating PMP and EMP levels are associated with CAS,which plays important roles in the progress of CAS patients.

关 键 词：颈动脉狭窄 血小板微粒体 内皮细胞微粒体 

分 类 号：R543.4[医药卫生—心血管疾病]