淫羊藿提取物的抗炎作用及其机制  

Anti-inflammatory Effects and Underlying Mechanisms of Epimedium Extracts

作　　者：马登磊 张兰[1] 李林[1] MADeng-Lei;ZHANG Lan;LI Lin(Department of Pharmacy,Xuanwu Hospital of Capital Medical University,National Clinical Research Center for Geriatric Diseases,Beijing Engineering Research Center for Nervous System Drugs,Beijing Institute for Brain Disorders,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院药学部,国家老年疾病临床医学研究中心,北京市神经药物工程技术研究中心,北京脑重大疾病研究院,神经变性病教育部重点实验室,北京100053

出　　处：《生物化学与生物物理进展》2020年第8期685-699,共15页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81673406,81874351);国家重大新药专项计划(2015ZX09101-016);北京市医院管理中心登峰计划专项(DFL20190803);首都科技领军人才培养工程(Z191100006119017);首都医科大学培育项目(PYZ19134)资助.

摘　　要：淫羊藿是一种常用的传统中药.黄酮类成分是淫羊藿的主要有效成分,其中淫羊藿苷是含量最高的单体成分,淫羊藿素是淫羊藿苷的代谢产物.最近10余年来,学者对淫羊藿提取物的药理作用进行了许多研究,表明淫羊藿黄酮,尤其是淫羊藿苷及其衍生物,在骨质疏松症、骨关节炎、神经和精神疾病、动脉粥样硬化、哮喘和肺部疾病、炎症性肠病、肾脏疾病、皮肤病、自身免疫性疾病和癌症等多个与慢性炎症有关的疾病模型中显示了良好的抗炎作用.淫羊藿苷及其衍生物发挥抗炎作用的分子机制主要包括降低炎症细胞因子释放和NF-κB信号通路激活,抑制NLRP3/caspase-1/IL-1β、STAT和MAPK介导的信号传导通路,上调Nrf2/ARE/HO-1信号通路以及糖皮质激素受体和雌激素受体下游信号通路等.本文综述了该领域的近期研究进展,提示淫羊藿及其所含的活性化合物具有治疗多种慢性炎症相关疾病的潜力.Herba Epimedii(yinyanghuo in Chinese)is a commonly used traditional Chinese medicine.Flavonoids are the major effective ingredient of Herba Epimedii,icariin is the most abundant component in Epimedium flavonoids,and icaritin is the metabolite of icariin.In the last decade,a number of studies on the pharmacological effects of Epimedium extracts have been conducted.Emerging evidence has shown that Epimedium flavonoids,especially icariin and its derivatives,have anti-inflammatory effects in the animal and cellular models on a variety of diseases related to chronic inflammation,including osteoporosis,osteoarthritis,neurological and psychiaric disorders,atherosclerosis,asthma and lung diseases,inflammatory bowel diseases,kidney diseases,skin diseases,autoimmune diseases,and cancer.The molecular mechanisms involved in anti-inflammation effects of icariin and its derivatives include reducing inflammatory cytokines,down-regulating NF-κB signaling,NLRP3/caspase-1/IL-1βaxis,STAT signaling and MAPK pathway,as well as up-regulating Nrf2/ARE/HO-1 pathway and increasing glucocorticoid receptor and estrogen receptor signaling.In this review,we have updated the recent advances in this field,and these studies have suggested that Epimedii and its active compounds have potential to treat multiple diseases related to chronic inflammation.

关 键 词：淫羊藿 中药 炎症 分子机制 

分 类 号：R285[医药卫生—中药学] R932[医药卫生—中医学]