中药通过调节小胶质细胞激活改善缺血性脑卒中  

Traditional Chinese Medicine Prevented Brain Injury via Regulating the Activation of Microglia After Ischemic Stroke

作　　者：周欣 楚世峰[1] 刘家琦 刘应蛟 许鑫 贺文斌 张玮[4] 陈乃宏[1] ZHOU Xin;CHU Shi-Feng;LIU Jia-Qi;LIU Ying-Jiao;XU Xin;HEWen-Bin;ZHANGWei;CHEN Nai-Hong(State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medical&Neuroscience Center,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Engineering Technology Research Center of Traditional Chinese Medicine decoction pieces Standardization and Function in Hunan Province,Changsha 410208,China;Shanxi Key Laboratory of Chinese Medicine Encephalopathy,Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China;Institute of Chinese Integrative Medicine,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]天然药物活性物质与功能国家重点实验室,中国医学科学院北京协和医学院药物研究所,北京100050 [2]湖南中医药大学药学院,长沙410208 [3]山西中医药大学中医脑病学山西重点实验室,太原030024 [4]河北医科大学中医药研究所,石家庄050017

出　　处：《生物化学与生物物理进展》2020年第8期700-711,共12页Progress In Biochemistry and Biophysics

基　　金：自然科学基金(81873026,81730096,81973499);北京自然科学基金(7192135);CAMS医学创新基金(CIFMS)(2016-I2M-1-004);新药机理与药理评价研究重点实验室研究计划(BZ0150);山西省重点研发计划(201803D421006)资助项目.

摘　　要：炎症反应是造成脑卒中继发性脑损伤的关键因素之一.小胶质细胞作为脑内免疫细胞,在脑卒中的炎症反应具有重要作用.传统观念认为小胶质细胞促进炎症反应加重脑损伤.近年来的研究发现,激活的小胶质细胞还能产生抗炎作用来加速脑损伤修复.因此,目前的研究将小胶质细胞分为促炎的M1型和抗炎的M2型.结合目前缺血性脑卒中的神经保护剂相对较少,靶向调控小胶质细胞的极化可能成为脑卒中新的治疗策略.研究发现中药能够通过抑制M1型小胶质细胞,并促进M2型的小胶质细胞来改善缺血性脑损伤,从而展现出对缺血性脑卒中的治疗潜力.本文综述中药通过调节小胶质细胞极化表型来治疗脑卒中的相关研究,以期为缺血性脑卒中药物开发提供新的思路.Inflammation plays a vital role in the pathophysiology of ischemic stroke.Resident microglia are the first to respond to inflammatory response in cerebral ischemia.Traditionally,Microglia are regard as an important contributor to inflammation to aggravate brain injury.However,Recent studies have found that activated microglia exert anti-inflammatory production against ischemic injury.Future therapies targeting microglia may not exclusively aim at suppressing microglia activation,but also at modulating microglia polarization at different stages of ischemic stroke.With lacking effective therapy strategies for stroke,considerable attention has been attracted by traditional Chinese Medicine(TCM).Many studies have reported that TCM protects ischemic injury by inhibiting activation of microglia and promote the different polarization of microglia phenotypes.The effects of TCM in mediating microglia activation and polarization during cerebral ischemia need to be further studied.

关 键 词：脑卒中 小胶质细胞 炎症 中药 

分 类 号：R967[医药卫生—药理学] R285.5[医药卫生—药学]