加味异功散联合常规疗法治疗小儿抗生素相关性腹泻临床研究  

Clinical Study on Modified Yigong Powder Combined with Conventional Treatment for Antibiotic Associated Diarrhea in Children

作　　者：屠徐飞 吴志强 陈霞萍 朱卫慧 TU Xufei;WU Zhiqiang;CHEN Xiaping;ZHU Weihui

机构地区：[1]湖州市南浔区人民医院儿科,浙江湖州313009

出　　处：《新中医》2020年第15期32-35,共4页New Chinese Medicine

摘　　要：目的:观察加味异功散联合常规疗法治疗小儿抗生素相关性腹泻(AAD)的临床疗效。方法:将108例脾胃虚寒证患儿随机分为对照组和观察组各54例。2组均给予防止水、电解质与酸碱平衡紊乱,营养支持等措施,并服用双歧杆菌三联活菌散、蒙脱石散、匹多莫德颗粒剂,观察组予加味异功散内服。2组疗程均为7 d。治疗前后评定中医证候评分,每天记录患儿的大便次数及形状,记录大便次数≤3次的时间和大便成形时间;统计治疗结束后7 d内,病情好转的患儿腹泻症状再次加重的情况,计算复发率。结果:治疗后,观察组疾病疗效和中医证候疗效均优于对照组(P<0.05)。2组大便次数评分、大便形状评分、证候积分与治疗前比较均下降(P<0.01);观察组大便次数评分、大便形状评分、证候积分均低于对照组(P<0.01)。观察组大便次数≤3次的时间和大便成形时间均较对照组加快(P<0.01)。治疗结束后7 d内,观察组复发率为7.84%,对照组复发率为23.81%,2组复发率比较,差异有统计学意义(P<0.05)。结论:加味异功散联合常规疗法治疗AAD脾胃虚寒证患儿,能有效减轻症状,缩短病程,降低复发率,临床疗效确切。Objective:To observe the clinical effect of modified Yigong powder combined with conventional treatment for antibiotic associated diarrhea(AAD)in children.Methods:A total of 108 children with syndrome of deficiency-cold of the spleen and stomach were randomly divided into the control group and the observation group,54 cases in each group.Both groups were given measures to prevent the imbalance of water,electrolyte,acid and base,and nutritional support,and were given bifidobacterium trifecta powder,montmorillonite powder and pitomod granule;the observation group was additionally treated with internal administration of modified Yigong powder.The treatment course of both groups was seven days.The Chinese medicine syndrome score was assessed before and after treatment,and the stool frequency and shape of the children every day were recorded,and the stool frequency less than three times and the stool forming time were recorded.The children who were in a better condition but had worse symptom of diarrhea again seven days after treatment were recorded,and the recurrence rate was calculated.Results:After treatment,the therapeutic effect of disease and Chinese medicine syndrome in the observation group were better than those in the control group(P<0.05).The scores of stool frequency,stool shape and syndrome after treatment in the two groups were all decreased when compared with those before treatment(P<0.01),and the above scores after treatment in the observation group were lower than those in the control group(P<0.01).The stool frequency less than three times and the forming time of defecation in the observation group were faster than those in the control group(P<0.01).Within seven days after treatment,the recurrence rate was 7.84% in the observation group and 23.81% in the control group,the difference being significant(P<0.05).Conclusion:The therapy of modified Yigong powder combined with conventional treatment for AAD children with syndrome of deficiency-cold of the spleen and stomach can effectively relieve symptoms,s

关 键 词：抗生素相关性腹泻 儿童 脾胃虚寒证 中西医结合疗法 异功散 

分 类 号：R725.7[医药卫生—儿科]