补肾益精汤联合胰激肽原酶治疗肾精亏虚证少精子症临床研究  

Clinical Study on Bushen Yijing Tang Combined with Pancreatic Kininogenase for Oligospermia with Kidney Meridian Deficiency Syndrome

作　　者：陈朋飞 CHEN Pengfei

机构地区：[1]河南科技大学附属许昌市中心医院泌尿外科、男科,河南许昌461000

出　　处：《新中医》2020年第15期109-112,共4页New Chinese Medicine

摘　　要：目的:观察补肾益精汤联合胰激肽原酶治疗肾精亏虚证少精子症的临床疗效。方法:将肾精亏虚证少精子症患者120例随机分为2组,对照组60例给予胰激肽原酶治疗,观察组60例在对照组的基础上加用补肾益精汤治疗。观察比较2组治疗前后精子质量,血清黄体生成素(LH)、卵泡刺激素(FSH)、雌激素(E2)、睾酮(T)水平变化,治疗后2组精液精浆活性氧(ROS)、丙二醛(MDA)、过氧化物歧化酶(SOD)水平,2组内环境相关指标精浆酸性磷酸酶(ACP)、腺苷酸环化酶(AC)、磷酸二酯酶(PDE)水平。结果:总有效率观察组为90.0%,对照组为73.3%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者精子密度、a级活力、a+b级活力、a+b+c级活力、精子正常形态率等均较治疗前显著改善(P<0.05),且治疗组上述各项指标改善较对照组更显著(P<0.05)。2组治疗前后精液量变化均无明显差异(P>0.05)。治疗后,2组患者T、E2、FSH、LH水平均较治疗前明显升高(P<0.05),且观察组T、E2、FSH、LH水平均高于对照组(P<0.05)。治疗后,观察组患者ROS、MDA水平低于对照组,SOD水平高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者ACP、AC水平高于对照组,PDE水平低于对照组,差异均有统计学意义(P<0.05)。结论:补肾益精汤联合胰激肽原酶治疗肾精亏虚证少精子症,可提高患者精子数量和质量,降低氧化应激反应,改善精子生存的内环境。Objective:To observe the clinical effect of Bushen Yijing tang combined with pancreatic kininogenase for patients with oligospermia with kidney meridian deficiency syndrome.Methods:A total of 120 cases of patients with oligospermia with kidney meridian deficiency syndrome were randomly divided into two groups,60 cases in each group.The control group was treated with pancreatic kininogenase,and the observation group was additionally treated with Bushen Yijing tang based on the treatmentof the control group.The sperm quality,changes in the levels of luteinizing hormone(LH),follicle stimulating hormone(FSH),estrogen(E2),and testosterone(T)in serum before and after treatment,and the reactive oxygen species(ROS),malondialdehyde(MDA)and superoxide dismutase(SOD)in semen and seminal plasma as well as the levels of internal environment-related indexes including acid phosphatase(ACP),adenylate cyclase(AC)and phosphodiesterase(PDE)in seminal plasma after treatment in the two groups were observed and compared.Results:The total effective rate was 90.0% in the observation group and 73.3% in the control group,the difference being significant(P<0.05).After treatment,the sperm density,a level,a+b level and a+b+c level of activity,and sperm normal morphology rates in the two groups were significantly improved when compared with those before treatment(P<0.05),and the improvement of the above indexes in the treatment group was more significant than that in the control group(P<0.05).Before and after treatment,there was no significant difference in the comparison of changes in semen volume between the two groups(P>0.05).After treatment,the levels of T,E2,FSH and LH in the two groups were significantly increased when compared with those before treatment(P<0.05),and the above levels in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of ROS and MDA in the observation group were lower than those in the control group,and SOD level was higher,differences being significant(P<0.05).After t

关 键 词：少精子症 肾经虚亏 补肾益精汤 胰激肽原酶 氧化应激 

分 类 号：R698.2[医药卫生—泌尿科学]