调心安神针法联合常规西药治疗心律失常临床研究  

Clinical Study on Tiaoxin Anshen Needling Method Combined with Routine Western Medicine for Arrhythmia

作　　者：陶纬经 殷建权[2] TAO Weijing;YIN Jianquan

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江省人民医院,浙江杭州310012

出　　处：《新中医》2020年第15期132-135,共4页New Chinese Medicine

摘　　要：目的:观察调心安神针法联合常规西药治疗心律失常的疗效。方法:选取158例心律失常患者,随机分为试验组和对照组各79例。对照组采取常规西药治疗,试验组在对照组基础上采取调心安神针法治疗,2组均治疗2周。观察2组疗效,比较治疗前、治疗2周后心功能指标[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)]、心率变异性指标[高频功率(HF)、低频功率(LF)、全程相邻窦性心搏间期之差的均方根(RMSSD)、每5分钟窦性心搏间期平均值的标准差(SDANN)]、细胞凋亡指标(C-myc、Bcl-2蛋白),随访6个月,比较2组复发率及世界卫生组织生活质量简表(WHOQOL-BREF)评分。结果:试验组总有效率为94.94%,高于对照组的83.54%(P<0.05)。治疗2周后,2组LVEF、HF、LF、RMSSD、SDANN、Bcl-2水平较治疗前提高,且试验组LVEF、HF、LF、RMSSD、SDANN、Bcl-2水平高于对照组;2组LVEDD、C-myc水平较治疗前降低,且试验组LVEDD、C-myc水平低于对照组(P<0.05)。治疗后6个月,2组WHOQOL-BREF评分较治疗前提高,且试验组WHOQOL-BREF评分高于对照组(P<0.05)。随访6个月,试验组复发率为2.67%(2/75),对照组复发率为15.15%(10/66),组间比较,差异有统计学意义(P<0.05)。结论:调心安神针法联合常规西药治疗心律失常可显著提升疗效,改善患者的心功能及心率变异性,提高C-myc、Bcl-2蛋白表达,抑制细胞凋亡,提升生活质量,降低复发率。Objective:To observe the curative effect of Tiaoxin Anshen needling method combined with routine western medicine for arrhythmia.Methods:A total of 158 cases of patients with arrhythmia were selected and randomly divided into the experiment group and the control group,79 cases in each group.The control group was given routine western medicine,and the experiment group was given Tiaoxin Anshen needling method based on the treatment of the control group.Both groups were treated for two weeks.The curative effect in the two groups was observed;the heart function indexes including left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD),the indexes of the heart rate variability such as high frequency power(HF),low frequency power(LF),the root mean square of the successive differences of sinus inter-beat interval(RMSSD),and the standard deviation of the averages of normal-to-normal inter-beat interval of sinus in all 5-minute segments(SDANN),as well as apoptosis indexes including C-myc and Bcl-2 protein in the two groups before treatment were compared with those after two-week treatment.During the six-month follow-up,the recurrence rate and scores of the World Health Organization Quality of Life Assessment-Brief Version(WHOQOL-BREF)were compared between the two groups.Results:The total effective rate was 94.94%in the experiment group,higher than that of 83.54%in the control group(P<0.05).After two-week treatment,LVEF,HF,LF,RMSSD and SDANN,as well as Bcl-2 levels in the two groups were increased when compared with those before treatment,and the five indexes and the level in the experiment group were higher than those in the control group;LVEDD and C-myc levels in the two groups were decreased when compared with those before treatment,and the index and the level in the experiment group were lower than those in the control group(P<0.05).In the six month after treatment,the scores of WHOQOL-BREF in the two groups were increased when compared with those before treatment,and the score in the

关 键 词：心律失常 调心安神针法 细胞凋亡 心功能 心率变异性 C-MYC BCL-2 

分 类 号：R541.7[医药卫生—心血管疾病] R246.1[医药卫生—内科学]